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11/15/2019 9:25:09 AM | Browse: 59 | Download: 58
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 46900
Country of Manuscript Source United Arab Emirates
Received
2019-03-06 02:25
Peer-Review Started
2019-03-08 03:26
To Make the First Decision
2019-04-16 07:33
Return for Revision
2019-05-09 09:34
Revised
2019-07-27 13:42
Second Decision
2019-09-12 10:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-09-12 21:33
Articles in Press
2019-09-12 21:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-11-05 01:33
Publish the Manuscript Online
2019-11-15 07:45
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Oncology
Manuscript Type Basic Study
Article Title Calponin 3 promotes invasion and drug resistance of colon cancer cells
Manuscript Source Unsolicited Manuscript
All Author List Vidhya A Nair, Noura Al-khayyal, Sivaramakrishnan Sivaperumal and Wael M Abdel-Rahman
Funding Agency and Grant Number
Corresponding author Wael M Abdel-Rahman, MD, PhD, Professor, Full Professor, Department of Medical Laboratory Sciences, College of Health Sciences and Environment and Cancer Research Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates. whassan@sharjah.ac.ae
Keywords β-Catenin; Calponin 3; Colon cancer; Epithelial-mesenchymal transition; Invasion; Metastasis
Core Tip We hypothesized that Calponin 3 (CNN3) could play a role in carcinogenesis based upon its known biological functions. We showed that it is expressed in colon and breast cancer cells and it was associated with the metastatic phenotype in colon cancer via upregulating mesenchymal markers. CNN3 also improved the sensitivity to chemotherapy in these tumors. We also showed that it is linked to other carcinogenic pathways, such as extracellular signal-regulated kinase 1/2, β-Catenin, mutant p53, c-Jun, and heat shock protein 60 in colorectal cancer. Thus, CNN3 is a promising biomarker in colon cancer.
Publish Date 2019-11-15 07:45
Citation Nair VA, Al-khayyal NA, Sivaperumal S, Abdel-Rahman WM. Calponin 3 promotes invasion and drug resistance of colon cancer cells. World J Gastrointest Oncol 2019; 11(11): 971-982
Url https://www.wjgnet.com/1948-5204/full/v11/i11/971.htm
DOI https://dx.doi.org/10.4251/wjgo.v11.i11.971
Full Article (PDF) WJGO-11-971.pdf
Full Article (Word) WJGO-11-971.docx
Manuscript File 46900-Review.docx
Answering Reviewers 46900-Answering reviewers.pdf
Audio Core Tip 46900-Audio core tip.m4a
Biostatistics Review Certificate 46900-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 46900-Conflict-of-interest statement.pdf
Copyright License Agreement 46900-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 46900-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 46900-Language certificate.pdf
Peer-review Report 46900-Peer-review(s).pdf
Scientific Misconduct Check 46900-Scientific misconduct check.pdf
Scientific Editor Work List 46900-Scientific editor work list.pdf