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5/28/2019 12:12:53 AM | Browse: 72 | Download: 46
Publication Name World Journal of Hepatology
Manuscript ID 47079
Country of Manuscript Source Greece
Received
2019-03-06 05:29
Peer-Review Started
2019-03-07 10:31
To Make the First Decision
2019-04-02 02:36
Return for Revision
2019-04-11 06:12
Revised
2019-05-15 19:26
Second Decision
2019-05-17 07:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-05-21 18:03
Articles in Press
2019-05-21 18:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-05-23 19:26
Typeset the Manuscript
2019-05-25 07:10
Publish the Manuscript Online
2019-05-27 08:24
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Case Report
Article Title Successful treatment of noncirrhotic portal hypertension with eculizumab in paroxysmal nocturnal hemoglobinuria: A case report
Manuscript Source Unsolicited Manuscript
All Author List Alexandra Alexopoulou, Iliana Mani, Dina G Tiniakos, Flora Kontopidou, Ioanna Tsironi, Marina Noutsou, Helen Pantelidaki and Spyros P Dourakis
Funding Agency and Grant Number
Correspondence To Alexandra Alexopoulou, MD, PhD, Adjunct Professor, Associate Professor, 2nd Department of Medicine, Medical School, National and Kapodistrian University of Athens, Hippokration General Hospital, 114 Vas Sophias St, Athens 11527, Greece. alexopou@ath.forthnet.gr
Keywords Paroxysmal nocturnal hemoglobinuria; Idiopathic non-cirrhotic portal hypertension; Eculizumab; Case report
Core Tip Idiopathic non-cirrhotic portal hypertension (INCPH) diagnosis is based on liver histology, the clinical signs of portal hypertension and the exclusion of chronic liver diseases in the absence of portal and hepatic venous thrombosis. We describe a patient with paroxysmal nocturnal hemoglobinuria who presented with intravascular hemolysis, jaundice and refractory ascites. Abdominal portosystemic collaterals were evident in imaging without varices in endoscopy. Liver histology demonstrated portal venopathy, features of nodular regenerative hyperplasia and ischemic parenchymal changes without cirrhosis, all indicative of INCPH. Eculizumab treatment achieved improvement of hemolysis and reversion of biochemical and clinical manifestations of liver disease.
Publish Date 2019-05-27 08:24
Citation Alexopoulou A, Mani I, Tiniakos DG, Kontopidou F, Tsironi I, Noutsou M, Pantelidaki H, Dourakis SP. Successful treatment of noncirrhotic portal hypertension with eculizumab in paroxysmal nocturnal hemoglobinuria: A case report. World J Hepatol 2019; 11(5): 483-488
Url https://www.wjgnet.com/1948-5182/full/v11/i5/483.htm
DOI https://dx.doi.org/10.4254/wjh.v11.i5.483
Full Article (PDF) WJH-11-483.pdf
Full Article (Word) WJH-11-483.docx
Manuscript File FP6863_de5_CE1RUSHMS-2.docx
Answering Reviewers 47079-Answering reviewers.pdf
Audio Core Tip 47079-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 47079-Conflict-of-interest statement.pdf
Copyright License Agreement 47079-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 47079-Informed consent statement.pdf
Peer-review Report 47079-Peer-review(s).pdf
Scientific Misconduct Check 47079-Scientific misconduct check.pdf
Scientific Editor Work List 47079-Scientific editor work list.pdf