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6/26/2019 9:52:36 AM | Browse: 147 | Download: 113
Publication Name World Journal of Gastroenterology
Manuscript ID 47401
Country of Manuscript Source Turkey
Received
2019-03-20 01:46
Peer-Review Started
2019-03-20 06:47
To Make the First Decision
2019-04-08 00:44
Return for Revision
2019-04-08 07:11
Revised
2019-04-26 08:16
Second Decision
2019-05-08 08:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-05-08 16:06
Articles in Press
2019-05-08 16:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-06-19 03:53
Publish the Manuscript Online
2019-06-21 03:42
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Review
Article Title Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis
Manuscript Source Invited Manuscript
All Author List Alaattin Sen and Holger Stark
Funding Agency and Grant Number
Correspondence To Alaattin Sen, PhD, Academic Fellow, Academic Research, Chairman, Full Professor, Instructor, Professor, Research Scientist, Senior Lecturer, Senior Researcher, Senior Scientist, Dean/PI, Department of Molecular Biology and Genetics, Faculty of Life and Natural Sciences, Abdullah Gul University, Sumer Campus, Kocasinan, Kayseri 38080, Turkey. sena@agu.edu.tr
Keywords Cytochrome P450; Polymorphism; Function; Ulcerative colitis; Aetiology
Core Tip The role of cytochrome P450s (CYPs) genes in the pathogenesis of ulcerative colitis (UC). Extrahepatic and extrarenal CYPs (e.g., macrophages and dendritic cells of colonic mucosa) have a critical role in UC development. Polymorphisms discussed can result in dysregulation of these enzymes in favour of alternative pathways producing more reactive metabolites. Production of reactive metabolites is favouring more severe disease states. Pharmacogenetics might facilitate individualized medicine for UC in the future although actually available data is limited.
Publish Date 2019-06-21 03:42
Citation Sen A, Stark H. Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis. World J Gastroenterol 2019; 25(23): 2846-2862
Url https://www.wjgnet.com/1007-9327/full/v25/i23/2846.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i23.2846
Full Article (PDF) WJG-25-2846.pdf
Full Article (Word) WJG-25-2846.docx
Manuscript File 47401-Review.docx
Answering Reviewers 47401-Answering reviewers.pdf
Audio Core Tip 47401-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 47401-Conflict-of-interest statement.pdf
Copyright License Agreement 47401-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 47401-Language certificate.pdf
Peer-review Report 47401-Peer-review(s).pdf
Scientific Misconduct Check 47401-Google-MA RY-1.png
Scientific Misconduct Check 47401-Google-MA RY-2.png
Scientific Misconduct Check 47401-Scientific misconduct check.pdf
Scientific Editor Work List 47401-Scientific editor work list.pdf