Publication Name	World Journal of Hepatology
Manuscript ID	47485
Country	Italy

Received	2019-03-15 03:11
Peer-Review Started	2019-03-15 06:29
First Decision by Editorial Office Director	2019-04-11 06:55
Return for Revision	2019-04-22 10:21
Revised	2019-05-16 14:07
Publication Fee Transferred
Second Decision by Editor	2019-05-17 07:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2019-05-21 06:12
Articles in Press	2019-05-21 06:12
Edit the Manuscript by Language Editor	2019-05-24 19:09
Typeset the Manuscript	2019-06-27 08:22
Publish the Manuscript Online	2019-06-27 10:40

ISSN	1948-5182 (online)
Open Access
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Dietary approach and gut microbiota modulation for chronic hepatic encephalopathy in cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Daniela Campion, Ilaria Giovo, Paola Ponzo, Giorgio M Saracco, Federico Balzola and Carlo Alessandria
Funding Agency and Grant Number
Corresponding Author	Carlo Alessandria, MD, Doctor, Doctor, Division of Gastroenterology and Hepatology, Città della Salute e della Scienza di Torino Hospital, University of Turin, C.so Bramante 88, Turin 10126, Italy. carloalessandria@libero.it
Key Words	Cirrhosis; Hepatic encephalopathy; Diet therapy; Gut microbiota; Leaky gut; Hyperammonemia; Prebiotics; Probiotics; Gluten-casein free diet; Gut microbiota transplantation
Core Tip	Hepatic encephalopathy (HE) is a serious complication of cirrhosis resulting from a multifactorial impairment of gut-liver-brain axis functioning. Multiple interrelated factors (e.g., intestinal hyperpermeability, dysbiosis, hyperammonemia, inflammation) cooperate in its development. “Gut-centric” therapies, including non-absorbable disaccharides, antibiotics, prebiotics, probiotics, and fecal microbiota transplantation have been successfully employed to manage HE: pertinent current knowledge will be reviewed. Furthermore, the utility of dietary modifications in this context is increasingly recognized, thus opening a new promising research path. This review sheds light on dietary therapeutic strategies for HE, exploring how they can target the mechanisms underlying gut-liver-brain axis dysregulation.
Publish Date	2019-06-27 10:40
Citation	Campion D, Giovo I, Ponzo P, Saracco GM, Balzola F, Alessandria C. Dietary approach and gut microbiota modulation for chronic hepatic encephalopathy in cirrhosis. World J Hepatol 2019; 11(6): 489-512
URL	https://www.wjgnet.com/1948-5182/full/v11/i6/489.htm
DOI	https://dx.doi.org/10.4254/wjh.v11.i6.489

Full Article (PDF)	WJH-11-489.pdf
Full Article (Word)	WJH-11-489.docx