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6/28/2019 8:01:23 AM | Browse: 163 | Download: 149
Publication Name World Journal of Hepatology
Manuscript ID 47485
Country of Manuscript Source Italy
Received
2019-03-15 03:11
Peer-Review Started
2019-03-15 06:29
To Make the First Decision
2019-04-17 02:26
Return for Revision
2019-04-22 10:21
Revised
2019-05-16 14:07
Second Decision
2019-05-17 07:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-05-21 06:12
Articles in Press
2019-05-21 06:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-05-24 19:09
Typeset the Manuscript
2019-06-27 08:22
Publish the Manuscript Online
2019-06-27 10:40
ISSN 1948-5182 (online)
Open Access
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Review
Article Title Dietary approach and gut microbiota modulation for chronic hepatic encephalopathy in cirrhosis
Manuscript Source Invited Manuscript
All Author List Daniela Campion, Ilaria Giovo, Paola Ponzo, Giorgio M Saracco, Federico Balzola and Carlo Alessandria
Funding Agency and Grant Number
Correspondence To Carlo Alessandria, MD, Doctor, Division of Gastroenterology and Hepatology, Città della Salute e della Scienza di Torino Hospital, University of Turin, C.so Bramante 88, Turin 10126, Italy. carloalessandria@libero.it
Keywords Cirrhosis; Hepatic encephalopathy; Diet therapy; Gut microbiota; Leaky gut; Hyperammonemia; Prebiotics; Probiotics; Gluten-casein free diet; Gut microbiota transplantation
Core Tip Hepatic encephalopathy (HE) is a serious complication of cirrhosis resulting from a multifactorial impairment of gut-liver-brain axis functioning. Multiple interrelated factors (e.g., intestinal hyperpermeability, dysbiosis, hyperammonemia, inflammation) cooperate in its development. “Gut-centric” therapies, including non-absorbable disaccharides, antibiotics, prebiotics, probiotics, and fecal microbiota transplantation have been successfully employed to manage HE: pertinent current knowledge will be reviewed. Furthermore, the utility of dietary modifications in this context is increasingly recognized, thus opening a new promising research path. This review sheds light on dietary therapeutic strategies for HE, exploring how they can target the mechanisms underlying gut-liver-brain axis dysregulation.
Publish Date 2019-06-27 10:40
Citation Campion D, Giovo I, Ponzo P, Saracco GM, Balzola F, Alessandria C. Dietary approach and gut microbiota modulation for chronic hepatic encephalopathy in cirrhosis. World J Hepatol 2019; 11(6): 489-512
Url https://www.wjgnet.com/1948-5182/full/v11/i6/489.htm
DOI https://dx.doi.org/10.4254/wjh.v11.i6.489
Full Article (PDF) WJH-11-489.pdf
Full Article (Word) WJH-11-489.docx
Manuscript File FP6864_de5_CE1RUSHMS-2.docx
Answering Reviewers 47485-Answering reviewers.pdf
Audio Core Tip 47485-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 47485-Conflict-of-interest statement.pdf
Copyright License Agreement 47485-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 47485-Language certificate.pdf
Peer-review Report 47485-Peer-review(s).pdf
Scientific Misconduct Check 47485-Scientific misconduct check.pdf
Scientific Editor Work List 47485-Scientific editor work list.pdf