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11/15/2019 9:24:27 AM | Browse: 49 | Download: 55
Publication Name World Journal of Stem Cells
Manuscript ID 47658
Country of Manuscript Source France
Received
2019-03-26 01:39
Peer-Review Started
2019-03-28 09:09
To Make the First Decision
2019-08-06 02:54
Return for Revision
2019-08-07 09:39
Revised
2019-08-29 07:28
Second Decision
2019-09-06 10:03
Accepted by Journal Editor-in-Chief
2019-09-07 00:49
Accepted by Company Editor-in-Chief
2019-09-11 19:05
Articles in Press
2019-09-11 19:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-09-18 21:15
Typeset the Manuscript
2019-10-30 10:17
Publish the Manuscript Online
2019-11-05 08:52
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Cell Biology
Manuscript Type Review
Article Title Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies
Manuscript Source Invited Manuscript
All Author List Audrey Vincent, Aïcha Ouelkdite-Oumouchal, Mouloud Souidi, Julie Leclerc, Bernadette Neve and Isabelle Van Seuningen
Funding Agency and Grant Number
Funding Agency Grant Number
Institut National de la Santé et de la Recherche Médicale” (Inserm)
“Centre National de la Recherche Scientifique” (CNRS)
“la Ligue Nationale contre le Cancer” (Committees 59, 60 and 62).
Corresponding author Isabelle Van Seuningen, PhD, Academic Research, Director, Research Scientist, Senior Scientist, Laboratory Director, JPArc/Team "Mucins, Epithelial Differentiation and Carcinogenesis", Inserm, UMR-S 1172, Jean Pierre Aubert Research Center, Team "Mucins, Epithelial Differentiation and Carcinogenesis," rue Polonovski, Bâtiment Cancer, Lille cedex 59045, France. isabelle.vanseuningen@inserm.fr
Keywords Cancer stem cells; Colon cancer; Epigenetics; Chromatin modifying enzymes; CD44; CD133
Core Tip The recent discovery of cancer cell plasticity, i.e. their ability to reprogram into cancer stem cells either naturally or under chemotherapy and/or radiotherapy has changed, once again, the way we consider cancer treatment. In this review, we try to understand why current epigenetic treatments have failed to prove their efficacy in solid tumors including colorectal cancer and we hypothesize that, using correlation tools comparing associations of relevant cancer stem cell markers with chromatin modifier expression, we may identify better candidates for epienzyme targeting.
Publish Date 2019-11-05 08:52
Citation Vincent A, Ouelkdite-Oumouchal A, Souidi M, Leclerc J, Neve B, Van Seuningen I. Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies. World J Stem Cells 2019; 11(11):920-936
Url https://www.wjgnet.com/1948-0210/full/v11/i11/920.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i11.920
Full Article (PDF) WJSC-11-920.pdf
Full Article (Word) WJSC-11-920.docx
Manuscript File FP7011_ce5_CE1MS-edit2.docx
Answering Reviewers 47658-Answering reviewers.pdf
Audio Core Tip 47658-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 47658-Conflict-of-interest statement.pdf
Copyright License Agreement 47658-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 47658-Language certificate.pdf
Peer-review Report 47658-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 47658-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 47658-Scientific misconduct check.pdf
Scientific Editor Work List 47658-Scientific editor work list.pdf