Publication Name	World Journal of Clinical Cases
Manuscript ID	47802
Country	Belgium

Received	2019-03-28 02:12
Peer-Review Started	2019-03-28 08:33
To Make the First Decision	2019-06-03 03:25
Return for Revision	2019-06-17 02:45
Revised	2019-09-05 15:18
Second Decision	2019-09-06 10:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-09-11 06:17
Articles in Press	2019-09-11 06:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-09-21 05:40
Publish the Manuscript Online	2019-09-29 10:56

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Research & Experimental Medicine
Manuscript Type	Systematic Reviews
Article Title	Treatment of laryngopharyngeal reflux disease: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Jerome R Lechien, Francois Mouawad, Maria R Barillari, Andrea Nacci, Seyyedeh Maryam Khoddami, Necati Enver, Sampath Kumar Raghunandhan, Christian Calvo-Henriquez, Young Gyu Eun and Sven Saussez
Funding Agency and Grant Number
Corresponding Author	Jerome R Lechien, MD, MSc, PhD, Associate Professor, Laboratory of Anatomy and Cell Biology, Faculty of Medicine, University of Mons (UMONS), Avenue du Champ de mars, Mons B7000, Belgium. jerome.lechien@umons.ac.be
Key Words	Laryngopharyngeal; Reflux; Laryngitis; Treatment; Proton pump inhibitors;
Core Tip	The treatment of laryngopharyngeal reflux disease (LPRD) has not changed since three decades and it is based on proton pump inhibitors (PPIs). However, the superiority of PPIs over placebo is still controversial and there are a significant number of non-responder patients to treatment. The development of multichannel intraluminal pH impedance monitoring led to the identification of subtypes of LPRD including acid, nonacid and mixed LPRD. The treatment of each subtype could be different in order to have better response rate.
Publish Date	2019-09-29 10:56
Citation	Lechien JR, Mouawad F, Barillari MR, Nacci A, Khoddami SM, Enver N, Raghunandhan SK, Calvo-Henriquez C, Eun YG, Saussez S. Treatment of laryngopharyngeal reflux disease: A systematic review. World J Clin Cases 2019; 7(19):2995-3011
URL	https://www.wjgnet.com/2307-8960/full/v7/i19/2995.htm
DOI	https://dx.doi.org/10.12998/wjcc.v7.i19.2995

Full Article (PDF)	WJCC-7-2995.pdf
Full Article (Word)	WJCC-7-2995.docx
Manuscript File	47802-Review.docx
Answering Reviewers	47802-Answering reviewers.pdf
Audio Core Tip	47802-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	47802-Conflict-of-interest statement.pdf
Copyright License Agreement	47802-Copyright license agreement.pdf
Peer-review Report	47802-Peer-review(s).pdf
Scientific Misconduct Check	47802-Scientific misconduct check.pdf
Scientific Editor Work List	47802-Scientific editor work list.pdf