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11/15/2019 9:24:27 AM | Browse: 57 | Download: 51
Publication Name World Journal of Stem Cells
Manuscript ID 49334
Country of Manuscript Source Czech Republic
Received
2019-05-25 06:23
Peer-Review Started
2019-05-27 00:52
To Make the First Decision
2019-08-06 02:52
Return for Revision
2019-08-28 07:22
Revised
2019-09-02 10:24
Second Decision
2019-09-12 10:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-09-14 15:58
Articles in Press
2019-09-14 15:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-09-27 23:48
Typeset the Manuscript
2019-10-27 10:18
Publish the Manuscript Online
2019-11-05 08:52
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Ophthalmology
Manuscript Type Review
Article Title Cytokine interplay among the diseased retina, inflammatory cells and mesenchymal stem cells - a clue to stem cell-based therapy
Manuscript Source Unsolicited Manuscript
All Author List Vladimir Holan, Barbora Hermankova, Magdalena Krulova and Alena Zajicova
Funding Agency and Grant Number
Funding Agency Grant Number
Grant Agency of the Czech Republic 17-04800S, 18-04393S and 19-02290S
Ministry of Education, Youth and Sports of the Czech Republic SVV 244-260435, NPU-I: LO1508 and NPU-I: LO1309
Corresponding author Vladimir Holan, PhD, Professor, research worker, Department of Transplantation Immunology, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, Prague 4 14220, Czech Republic. vladimir.holan@iem.cas.cz
Keywords Retina; Degenerative diseases; Stem cell therapy; Mesenchymal stem cells; Cytokines; Growth factors
Core Tip Cell-based therapy using autologous mesenchymal stem cells (MSCs) represents a perspective approach for the treatment of so far incurrable degenerative retinal diseases. However, the therapeutic potential of MSCs strongly depends on the cytokine environment, where these cells are delivered. In this study we discuss recent knowledge regarding the interactions and interplay among cytokines produced by cells of the diseased retina, inflammatory immune cells and therapeutically administered MSCs. We suggest that these interactions among cytokines and growth factors occurring in the microenvironment of the diseased retina could be critical for the outcome of the stem cell-based therapy for retinal disorders.
Publish Date 2019-11-05 08:52
Citation Holan V, Hermankova B, Krulova M, Zajicova A. Cytokine interplay among the diseased retina, inflammatory cells and mesenchymal stem cells - a clue to stem cell-based therapy. World J Stem Cells 2019; 11(11):957-967
Url https://www.wjgnet.com/1948-0210/full/v11/i11/957.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i11.957
Full Article (PDF) WJSC-11-957.pdf
Full Article (Word) WJSC-11-957.docx
Manuscript File WJSC-Korekce-27.9.2019.docx
Answering Reviewers 49334-Answering reviewers.pdf
Audio Core Tip 49334-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 49334-Conflict-of-interest statement.pdf
Copyright License Agreement 49334-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 49334-Language certificate.pdf
Peer-review Report 49334-Peer-review(s).pdf
Scientific Misconduct Check 49334-Scientific misconduct check.pdf
Scientific Editor Work List 49334-Scientific editor work list.pdf