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9/17/2019 1:24:08 AM | Browse: 207 | Download: 182
Publication Name World Journal of Gastroenterology
Manuscript ID 49431
Country/Territory Greece
2019-05-30 02:58
Peer-Review Started
2019-05-30 06:40
To Make the First Decision
2019-07-22 03:40
Return for Revision
2019-07-23 02:17
2019-07-30 07:48
Second Decision
2019-08-02 10:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-08-07 09:30
Articles in Press
2019-08-07 09:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-09-04 03:17
Publish the Manuscript Online
2019-09-07 04:43
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Editorial
Article Title Role of NLRP3 inflammasome in inflammatory bowel diseases
Manuscript Source Invited Manuscript
All Author List Evanthia Tourkochristou, Ioanna Aggeletopoulou, Christos Konstantakis and Christos Triantos
Funding Agency and Grant Number
Corresponding author Christos Triantos, FAASLD, MD, PhD, Assistant Professor, Senior Scientist, Division of Gastroenterology, Department of Internal Medicine, Medical School, University of Patras, D. Stamatopoulou 4, Patras 26504, Greece. chtriantos@upatras.gr
Keywords NLRP3 inflammasome; Inflammatory bowel diseases; Mucosal immune system; Interleukin 1β; Interleukin 18; NLRP3 gene polymorphisms
Core Tip NLRP3 inflammasome plays a major role in inflammatory bowel diseases (IBD) pathogenesis through its contribution to chronic inflammatory processes. Abnormal activation of NLRP3 inflammasome has been observed in inflamed tissue of IBD murine models and patients, highlighting its possible pathogenic role in the disease. However, protective effects of NLRP3 function have also been recorded. The pathogenic NLRP3 inflammasome activity in mucosal immune system may be implicated in the aberrant immune responses and in the disruption of intestinal homeostasis that characterizes IBD. Targeting NLRP3 inflammasome and its downstream signaling will provide new insights into the development of future therapeutic strategies.
Publish Date 2019-09-07 04:43
Citation Tourkochristou E, Aggeletopoulou I, Konstantakis C, Triantos C. Role of NLRP3 inflammasome in inflammatory bowel diseases. World J Gastroenterol 2019; 25(33): 4796-4804
Url https://www.wjgnet.com/1007-9327/full/v25/i33/4796.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i33.4796
Full Article (PDF) WJG-25-4796.pdf
Full Article (Word) WJG-25-4796.docx
Manuscript File 49431-Review.docx
Answering Reviewers 49431-Answering reviewers.pdf
Audio Core Tip 49431-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 49431-Conflict-of-interest statement.pdf
Copyright License Agreement 49431-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 49431-Language certificate.pdf
Peer-review Report 49431-Peer-review(s).pdf
Scientific Misconduct Check 49431-Scientific misconduct check.pdf
Scientific Editor Work List 49431-Scientific editor work list.pdf