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11/5/2019 9:02:40 AM | Browse: 12 | Download: 3
Publication Name World Journal of Gastroenterology
Manuscript ID 49448
Country of Manuscript Source Austria
Received
2019-06-04 00:50
Peer-Review Started
2019-06-04 06:17
To Make the First Decision
2019-07-22 02:21
Return for Revision
2019-07-22 07:18
Revised
2019-08-15 03:32
Second Decision
2019-09-20 09:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-09-28 04:49
Articles in Press
2019-09-28 04:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-10-18 05:04
Publish the Manuscript Online
2019-10-21 09:37
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Review
Article Title Gut-liver axis signaling in portal hypertension
Manuscript Source Invited Manuscript
All Author List Benedikt Simbrunner, Mattias Mandorfer, Michael Trauner and Thomas Reiberger
Funding Agency and Grant Number
Correspondence To Thomas Reiberger, MD, Associate Professor, Doctor, Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Spitalgasse 23, Vienna A-1090, Austria. thomas.reiberger@meduniwien.ac.at
Keywords Cirrhosis; Portal hypertension; Gut-liver axis; Bacterial translocation; Intestinal barrier; Farnesoid X receptor
Core Tip In advanced chronic liver disease, portal hypertension (PHT) results from increased intrahepatic resistance and leads to splanchnic vasodilation and neovascularization in the intestines. Gut dysbiosis, increased intestinal permeability, translocation of bacteria and pathogen-associated molecular patterns can further promote liver disease progression, often mediated via immune system activation and a subsequent induction of a proinflammatory state. The close relationship between gut and liver and their bidirectional interaction has been termed gut-liver axis. This review aims to connect the impact of PHT on the gut-liver axis by providing both insight into pathophysiology and clinical observations, as well as therapeutic strategies.
Publish Date 2019-10-21 09:37
Citation Simbrunner B, Mandorfer M, Trauner M, Reiberger T. Gut-liver axis signaling in portal hypertension. World J Gastroenterol 2019; 25(39): 5897-5917
Url https://www.wjgnet.com/1007-9327/full/v25/i39/5897.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i39.5897
Full Article (PDF) WJG-25-5897.pdf
Full Article (Word) WJG-25-5897.docx
Manuscript File 49448-Review.docx
Answering Reviewers 49448-Answering reviewers.pdf
Audio Core Tip 49448-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 49448-Conflict-of-interest statement.pdf
Copyright License Agreement 49448-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 49448-Language certificate.pdf
Supplementary Material 49448-Supplementary material.pdf
Peer-review Report 49448-Peer-review(s).pdf
Scientific Misconduct Check 49448-Bing-Tang JZ-2.png
Scientific Misconduct Check 49448-Scientific misconduct check.pdf
Scientific Editor Work List 49448-Scientific editor work list.pdf