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11/15/2019 9:23:29 AM | Browse: 542 | Download: 836
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Received |
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2019-06-05 00:55 |
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Peer-Review Started |
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2019-06-06 10:45 |
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To Make the First Decision |
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2019-09-16 03:55 |
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Return for Revision |
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2019-09-16 08:41 |
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Revised |
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2019-09-20 16:26 |
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Second Decision |
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2019-10-14 11:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-10-15 05:17 |
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Articles in Press |
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2019-10-15 05:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-11-04 03:04 |
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Publish the Manuscript Online |
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2019-11-08 04:22 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Retrospective Study |
| Article Title |
Efficient management of secondary haemophagocytic lymphohistiocytosis with intravenous steroids and γ-immunoglobulin infusions
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sarah Georgiadou, Nikolaos K Gatselis, Aggelos Stefos, Kalliopi Zachou, Konstantinos Makaritsis, Eirini I Rigopoulou and George N Dalekos |
| Funding Agency and Grant Number |
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| Corresponding Author |
George N Dalekos, MD, PhD, Chairman, Full Professor, Department of Medicine and Research Laboratory of Internal Medicine, University Hospital Larissa, Mezourlo, Larissa 41110, Greece. dalekos@med.uth.gr |
| Key Words |
Haemophagocytic syndrome; Haemophagocytic lymphohistiocytosis; γ-immunoglobulin; Leishmaniasis; Ferritin; |
| Core Tip |
This retrospective study analysed all adult patients (n = 80) with Secondary haemophagocytic lymphohistiocytosis (sHLH) diagnosed in our tertiary care hospital during 2010-2018 paying considerable attention on the treatment schedule and the outcome of patients. In our large cohort, infections were the major cause of sHLH (74% of patients) and therefore, they should be thoroughly investigated in such patients. sHLH still carries a remarkable morbidity and mortality as 15% of patients died within the first month. Early recognition and treatment with intravenous γ-immunoglobulin in association with intravenous corticosteroids seem an efficient treatment option for successful outcome in this life-threatening condition (resolution in 76%; 6-mo survival: 82.5%). |
| Publish Date |
2019-11-08 04:22 |
| Citation |
Georgiadou S, Gatselis NK, Stefos A, Zachou K, Makaritsis K, Rigopoulou EI, Dalekos GN. Efficient management of secondary haemophagocytic lymphohistiocytosis with intravenous steroids and γ-immunoglobulin infusions. World J Clin Cases 2019; 7(21):3394-3406 |
| URL |
https://www.wjgnet.com/2307-8960/full/v7/i21/3394.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v7.i21.3394 |
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