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11/15/2019 9:23:29 AM | Browse: 48 | Download: 78
Publication Name World Journal of Clinical Cases
Manuscript ID 49599
Country of Manuscript Source Greece
Received
2019-06-05 00:55
Peer-Review Started
2019-06-06 10:45
To Make the First Decision
2019-09-16 03:55
Return for Revision
2019-09-16 08:41
Revised
2019-09-20 16:26
Second Decision
2019-10-14 11:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-10-15 05:17
Articles in Press
2019-10-15 05:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-11-04 03:04
Publish the Manuscript Online
2019-11-08 04:22
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Medicine, General and Internal
Manuscript Type Retrospective Study
Article Title Efficient management of secondary haemophagocytic lymphohistiocytosis with intravenous steroids and γ-immunoglobulin infusions
Manuscript Source Unsolicited Manuscript
All Author List Sarah Georgiadou, Nikolaos K Gatselis, Aggelos Stefos, Kalliopi Zachou, Konstantinos Makaritsis, Eirini I Rigopoulou and George N Dalekos
Funding Agency and Grant Number
Corresponding author George N Dalekos, MD, PhD, Chairman, Full Professor, Department of Medicine and Research Laboratory of Internal Medicine, University Hospital Larissa, Mezourlo, Larissa 41110, Greece. dalekos@med.uth.gr
Keywords Haemophagocytic syndrome; Haemophagocytic lymphohistiocytosis; γ-immunoglobulin; Leishmaniasis; Ferritin;
Core Tip This retrospective study analysed all adult patients (n = 80) with Secondary haemophagocytic lymphohistiocytosis (sHLH) diagnosed in our tertiary care hospital during 2010-2018 paying considerable attention on the treatment schedule and the outcome of patients. In our large cohort, infections were the major cause of sHLH (74% of patients) and therefore, they should be thoroughly investigated in such patients. sHLH still carries a remarkable morbidity and mortality as 15% of patients died within the first month. Early recognition and treatment with intravenous γ-immunoglobulin in association with intravenous corticosteroids seem an efficient treatment option for successful outcome in this life-threatening condition (resolution in 76%; 6-mo survival: 82.5%).
Publish Date 2019-11-08 04:22
Citation Georgiadou S, Gatselis NK, Stefos A, Zachou K, Makaritsis K, Rigopoulou EI, Dalekos GN. Efficient management of secondary haemophagocytic lymphohistiocytosis with intravenous steroids and γ-immunoglobulin infusions. World J Clin Cases 2019; 7(21):3394-3406
Url https://www.wjgnet.com/2307-8960/full/v7/i21/3394.htm
DOI https://dx.doi.org/10.12998/wjcc.v7.i21.3394
Full Article (PDF) WJCC-7-3394.pdf
Full Article (Word) WJCC-7-3394.docx
Manuscript File 49599-Review.docx
Answering Reviewers 49599-Answering reviewers.pdf
Audio Core Tip 49599-Audio core tip.mp3
Biostatistics Review Certificate 49599-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 49599-Conflict-of-interest statement.pdf
Copyright License Agreement 49599-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 49599-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 49599-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 49599-Language certificate.pdf
Peer-review Report 49599-Peer-review(s).pdf
Scientific Misconduct Check 49599-Scientific misconduct check.pdf
Scientific Editor Work List 49599-Scientific editor work list.pdf