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1/14/2020 2:35:12 AM | Browse: 123 | Download: 111
Publication Name World Journal of Stem Cells
Manuscript ID 49995
Country/Territory New Zealand
Received
2019-06-25 08:38
Peer-Review Started
2019-06-29 04:57
To Make the First Decision
2019-08-06 02:50
Return for Revision
2019-08-26 09:32
Revised
2019-10-24 23:34
Second Decision
2019-11-06 03:28
Accepted by Journal Editor-in-Chief
2019-11-06 21:48
Accepted by Company Editor-in-Chief
2019-11-13 19:21
Articles in Press
2019-11-13 19:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-11-27 23:09
Typeset the Manuscript
2019-12-17 09:41
Publish the Manuscript Online
2019-12-30 01:55
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Basic Study
Article Title Sphere-forming corneal cells repopulate dystrophic keratoconic stroma: Implications for potential therapy
Manuscript Source Unsolicited Manuscript
All Author List Himanshu Wadhwa, Salim Ismail, Jennifer J McGhee, Bert Van der Werf and Trevor Sherwin
Funding Agency and Grant Number
Funding Agency Grant Number
Save Sight Society of New Zealand 37116543
Auckland Medical Research Foundation 1111010
New Zealand Wound Care Society 3713325
John Hamel MacGregor Trust
Corresponding author Trevor Sherwin, PhD, Professor, Department of Ophthalmology, The University of Auckland, Private Bag 92019, Auckland, 1010, New Zealand. t.sherwin@auckland.ac.nz., Auckland 1023, Auckland, New Zealand. t.sherwin@auckland.ac.nz
Keywords Keratoconus; Cell culture; Immunohistochemistry; Quantitative PCR; Digital PCR; Spheroid
Core Tip Keratoconus is a degenerative corneal disease characterised by aberrant cell behaviour and loss of matrix that can result in vision loss. Cells extracted from peripheral corneas can form stem cell-enriched spheres, which we introduced into normal and keratoconic corneal stroma. This study shows for the first time that implanted stem cell-enriched spheres are capable of repopulating the dystrophic corneal stromal surface in a directed manner. Spheres may therefore be used to replace or supplement diseased cells in keratoconic patients, thereby serving as an adjunct to current treatments.
Publish Date 2019-12-30 01:55
Citation Wadhwa H, Ismail S, McGhee JJ, Van der Werf B, Sherwin T. Sphere-forming corneal cells repopulate dystrophic keratoconic stroma: Implications for potential therapy. World J Stem Cells 2020; 12(1): 35-54
Url https://www.wjgnet.com/1948-0210/full/v12/i1/35.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i1.35
Full Article (PDF) WJSC-12-35.pdf
Full Article (Word) WJSC-12-35.docx
Manuscript File FP7080_ce16_CE1MS_edit2.docx
Answering Reviewers 49995-Answering reviewers.pdf
Audio Core Tip 49995-Audio core tip.mp3
Biostatistics Review Certificate 49995-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 49995-Conflict-of-interest statement.pdf
Copyright License Agreement 49995-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 49995-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 49995-Institutional review board statement.pdf
Peer-review Report 49995-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 49995-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 49995-Scientific misconduct check.pdf
Scientific Editor Work List 49995-Scientific editor work list.pdf