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1/14/2020 2:35:12 AM | Browse: 416 | Download: 795
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Received |
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2019-06-25 08:38 |
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Peer-Review Started |
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2019-06-29 04:57 |
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To Make the First Decision |
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2019-08-06 02:50 |
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Return for Revision |
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2019-08-26 09:32 |
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Revised |
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2019-10-24 23:34 |
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Second Decision |
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2019-11-06 03:28 |
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Accepted by Journal Editor-in-Chief |
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2019-11-06 21:48 |
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Accepted by Company Editor-in-Chief |
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2019-11-13 19:21 |
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Articles in Press |
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2019-11-13 19:21 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-11-27 23:09 |
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Typeset the Manuscript |
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2019-12-17 09:41 |
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Publish the Manuscript Online |
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2019-12-30 01:55 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Sphere-forming corneal cells repopulate dystrophic keratoconic stroma: Implications for potential therapy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Himanshu Wadhwa, Salim Ismail, Jennifer J McGhee, Bert Van der Werf and Trevor Sherwin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Save Sight Society of New Zealand |
37116543 |
| Auckland Medical Research Foundation |
1111010 |
| New Zealand Wound Care Society |
3713325 |
| John Hamel MacGregor Trust |
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| Corresponding Author |
Trevor Sherwin, PhD, Professor, Department of Ophthalmology, The University of Auckland, Private Bag 92019, Auckland, 1010, New Zealand. t.sherwin@auckland.ac.nz., Auckland 1023, Auckland, New Zealand. t.sherwin@auckland.ac.nz |
| Key Words |
Keratoconus; Cell culture; Immunohistochemistry; Quantitative PCR; Digital PCR; Spheroid |
| Core Tip |
Keratoconus is a degenerative corneal disease characterised by aberrant cell behaviour and loss of matrix that can result in vision loss. Cells extracted from peripheral corneas can form stem cell-enriched spheres, which we introduced into normal and keratoconic corneal stroma. This study shows for the first time that implanted stem cell-enriched spheres are capable of repopulating the dystrophic corneal stromal surface in a directed manner. Spheres may therefore be used to replace or supplement diseased cells in keratoconic patients, thereby serving as an adjunct to current treatments. |
| Publish Date |
2019-12-30 01:55 |
| Citation |
Wadhwa H, Ismail S, McGhee JJ, Van der Werf B, Sherwin T. Sphere-forming corneal cells repopulate dystrophic keratoconic stroma: Implications for potential therapy. World J Stem Cells 2020; 12(1): 35-54 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i1/35.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i1.35 |
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