Publication Name	World Journal of Gastroenterology
Manuscript ID	50953
Country	Brazil

Received	2019-08-18 14:20
Peer-Review Started	2019-08-18 14:22
To Make the First Decision	2019-10-14 08:54
Return for Revision	2019-10-16 10:13
Revised	2019-10-22 15:01
Second Decision	2019-11-12 10:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-11-13 01:50
Articles in Press	2019-11-13 01:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-11-27 12:15
Publish the Manuscript Online	2019-11-28 10:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Inositol 1,4,5-trisphosphate receptor in the liver: Expression and function
Manuscript Source	Unsolicited Manuscript
All Author List	Fernanda de Oliveira Lemos, Rodrigo M Florentino, Antônio Carlos Melo Lima Filho, Marcone Loiola dos Santos and M Fatima Leite
Funding Agency and Grant Number	Funding Agency Grant Number CNPq CAPES FAPEMIG Liver Center at UFMG
Corresponding Author	M Fatima Leite, PhD, Full Professor, Department of Physiology and Biophysics, Federal University of Minas Gerais, Av. Presidente Antônio Carlos, 6627 - Pampulha, Belo Horizonte 31270-901, Minas Gerais, Brazil. leitemd@ufmg.br
Key Words	Inositol 1,4,5-trisphosphate receptor; Liver; Calcium signaling; Hepatocytes and cholangiocytes; ;
Core Tip	Calcium regulates a variety of functions in our body. In the liver, inositol 1,4,5-trisphosphate receptors (ITPR) are the only expressed intracellular calcium release channels. ITPR regulates liver functions under healthy situation, but they can also be involved in liver diseases, depending for instance, in which isoform is expressed in a specific cell type, level of expression and where inside the cell each isoform is expressed. In this review, we discuss about ITPR roles in hepatic cells in physiological and pathological conditions.
Publish Date	2019-11-28 10:38
Citation	Lemos FO, Florentino RM, Filho ACML, Santos ML, Leite MF. Inositol 1,4,5-trisphosphate receptor in the liver: Expression and function. World J Gastroenterol 2019; 25(44): 6483-6494
URL	https://www.wjgnet.com/1007-9327/full/v25/i44/6483.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i44.6483

Full Article (PDF)	WJG-25-6483.pdf
Full Article (Word)	WJG-25-6483.docx
Manuscript File	50953-Review.docx
Answering Reviewers	50953-Answering reviewers.pdf
Audio Core Tip	50953-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	50953-Conflict-of-interest statement.pdf
Copyright License Agreement	50953-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	50953-Language certificate.pdf
Peer-review Report	50953-Peer-review(s).pdf
Scientific Misconduct Check	50953-Scientific misconduct check.pdf
Scientific Editor Work List	50953-Scientific editor work list.pdf