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2/28/2020 10:02:29 AM | Browse: 63 | Download: 37
Publication Name World Journal of Stem Cells
Manuscript ID 51080
Country/Territory Taiwan
Received
2019-08-27 03:48
Peer-Review Started
2019-08-27 03:50
To Make the First Decision
2019-10-21 02:08
Return for Revision
2019-10-21 07:20
Revised
2019-12-27 00:14
Second Decision
2020-01-05 09:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-01-06 20:08
Articles in Press
2020-01-06 20:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-01-10 00:26
Typeset the Manuscript
2020-02-21 03:06
Publish the Manuscript Online
2020-02-27 07:06
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Basic Study
Article Title Comparison between the therapeutic effects of differentiated and undifferentiated Wharton's jelly mesenchymal stem cells in rats with streptozotocin-induced diabetes
Manuscript Source Unsolicited Manuscript
All Author List Chen-Yuan Hsiao, Tien-Hua Chen, Ben-Shian Huang, Po-Han Chen, Cheng-Hsi Su, Jia-Fwu Shyu and Pei-Jiun Tsai
Funding Agency and Grant Number
Funding Agency Grant Number
Taipei Veterans General Hospital V106B-024
Yen Tjing Ling Medical Foundation CI-106-20
Taiwan Ministry of Science and Technology MOST 105-2314-B-010-010-MY3
Cheng Hsin General Hospital CY10716
Taiwan Ministry of Science and Technology MOST 106-2314-B-010-009
Corresponding author Pei-Jiun Tsai, MD, PhD, Assistant Professor, Attending Doctor, Surgeon, Institute of Anatomy and Cell Biology, School of Medicine, National Yang Ming University, 201 Shih-Pai Road Section 2, Taipei 112, Taiwan. pjtsai@vghtpe.gov.tw
Keywords Human Wharton’s jelly mesenchymal stem cell; Insulin-producing cells; Diabetes mellitus; Differentiation; Regeneration therapy; Anti-inflammatory
Core Tip The therapeutic mechanism of differentiated and undifferentiated human Wharton’s Jelly mesenchymal stem cells in streptozotocin-induced diabetic rats may be different. Differentiated insulin producing cells can significantly improve blood glucose levels due to continuously secretion insulin by the transplanted cells that survived in the islets of diabetic rats. Transplantation of undifferentiated human Wharton’s Jelly mesenchymal stem cells can significantly improve insulitis and re-balance the inflammatory condition with only a slight improvement in blood glucose levels. The results of this study will provide basic and essential information for future application of cell regenerative therapy in diabetic patients.
Publish Date 2020-02-27 07:06
Citation Hsiao CY, Chen TH, Huang BS, Chen PH, Su CH, Shyu JF, Tsai PJ. Comparison between the therapeutic effects of differentiated and undifferentiated Wharton’s jelly mesenchymal stem cells in rats with streptozotocin-induced diabetes. World J Stem Cells 2020; 12(2): 139-151
Url https://www.wjgnet.com/1948-0210/full/v12/i2/139.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i2.139
Full Article (PDF) WJSC-12-139.pdf
Full Article (Word) WJSC-12-139.docx
Manuscript File 51080-Review.docx
Answering Reviewers 51080-Answering reviewers.pdf
Audio Core Tip 51080-Audio core tip.mp3
Biostatistics Review Certificate 51080-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 51080-Conflict-of-interest statement.pdf
Copyright License Agreement 51080-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 51080-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 51080-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 51080-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 51080-Language certificate.pdf
Supplementary Material 51080-Informed consent statement.pdf
Peer-review Report 51080-Peer-review(s).pdf
Scientific Misconduct Check 51080-Scientific misconduct check.pdf
Scientific Editor Work List 51080-Scientific editor work list.pdf