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12/3/2019 2:06:51 AM | Browse: 507 | Download: 250
Publication Name World Journal of Gastroenterology
Manuscript ID 51464
Country/Territory China
2019-09-18 15:42
Peer-Review Started
2019-09-18 15:43
To Make the First Decision
2019-10-14 09:33
Return for Revision
2019-10-16 01:35
2019-10-31 18:35
Second Decision
2019-11-12 11:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-11-13 01:45
Articles in Press
2019-11-13 01:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-11-19 08:53
Typeset the Manuscript
2019-11-27 12:14
Publish the Manuscript Online
2019-11-28 10:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry and Molecular Biology
Manuscript Type Basic Study
Article Title Gasdermin D-mediated hepatocyte pyroptosis expands inflammatory responses that aggravate acute liver failure by upregulating monocyte chemotactic protein 1/ CC chemokine receptor-2 to recruit macrophages
Manuscript Source Unsolicited Manuscript
All Author List Hong Li, Xue-Ke Zhao, Yi-Ju Cheng, Quan Zhang, Jun Wu, Shuang Lu, Wei Zhang, Yang Liu, Ming-Yu Zhou, Ya Wang, Jing Yang and Ming-Liang Cheng
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81570543
National Natural Science Foundation of China 81560104
Corresponding author Ming-Liang Cheng, BSc, Chief Physician, Professor, Prof., Department of Infectious Diseases, Affiliated Hospital of Guizhou Medical University, No.28,Guiyi Road, Guiyang 550004, Guizhou, China. mlcheng@yeah.net
Keywords Gasdermin D; Hepatocyte; Pyroptosis; Acute liver failure; Monocyte chemotactic protein 1/CC chemokine receptor-2;
Core Tip The expression of Gasdermin D-N terminal domain was significantly increased in the liver during human acute liver failure (ALF), in a D-galactose/lipopolysaccharide (D-Galn/LPS)-induced ALF mouse model and in D-Galn/LPS-treated AML12 hepatocytes. GSDMD-mediated hepatocyte pyroptosis expanded the inflammatory response by upregulating monocyte chemotactic protein 1 and its receptor CC chemokine receptor-2 to recruit macrophages. Knocking down GSDMD could significantly alleviate ALF in the mouse model. Finding effective intervention targets or drugs inhibiting GSDMD may provide a possible treatment approach to improve the outcomes of ALF.
Publish Date 2019-11-28 10:38
Citation Li H, Zhao XK, Cheng YJ, Zhang Q, Wu J, Lu S, Zhang W, Liu Y, Zhou MY, Wang Y, Yang J, Cheng ML. Gasdermin D-mediated hepatocyte pyroptosis expands inflammatory responses that aggravate acute liver failure by upregulating monocyte chemotactic protein 1/ CC chemokine receptor-2 to recruit macrophages. World J Gastroenterol 2019; 25(44): 6527-6540
Url https://www.wjgnet.com/1007-9327/full/v25/i44/6527.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i44.6527
Full Article (PDF) WJG-25-6527.pdf
Full Article (Word) WJG-25-6527.docx
Manuscript File 51464-Review_Edited.docx
Answering Reviewers 51464-Answering reviewers.pdf
Audio Core Tip 51464-Audio core tip.mp3
Biostatistics Review Certificate 51464-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 51464-Conflict-of-interest statement.pdf
Copyright License Agreement 51464-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 51464-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 51464-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 51464-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 51464-Language certificate.pdf
Peer-review Report 51464-Peer-review(s).pdf
Scientific Misconduct Check 51464-Bing-Tang JZ-2.png
Scientific Misconduct Check 51464-Scientific misconduct check.pdf
Scientific Editor Work List 51464-Scientific editor work list.pdf