| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Epigallocatechin gallate inhibits dimethylhydrazine-induced colorectal cancer in rats
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Wang, Hei-Ying Jin, Ming-Zhi Fang, Xiao-Feng Wang, Hao Chen, Shu-Liang Huang, De-Song Kong, Min Li, Xiu Zhang, Yu Sun and Shui-Ming Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Nursing Advantage Discipline Construction Project Foundation of Jiangsu Province University |
2019YSHL107 |
| Nanjing Medical Science and technique Development Foundation |
NWQR-201705 |
|
| Corresponding Author |
Shui-Ming Wang, MD, PhD, Attending Doctor, Research Scientist, National Center of Colorectal Disease, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, No. 157 Daming Road, Qinhuai District, Nanjing 210001, Jiangsu Province, China. watershuiming@hotmail.com |
| Key Words |
Epigallocatechin gallate; Dimethylhydrazine; Colorectal cancer; Aberrant crypt foci; Mitogen-activated protein kinase; The Cancer Genome Atlas |
| Core Tip |
Our research found that epigallocatechin gallate (EGCG) extracted from tea can inhibit the occurrence of colorectal cancer (CRC) in dimethylhydrazine-induced rat models and predicted the interaction between EGCG and CRC target genes using a bioinformatics database. The Cancer Genome Atlas database was used to further explore the significant differences of 28 genes among 78 intersection target genes and Kyoto Encyclopedia of Genes and Genomes and Gene ontology analyses were performed to explore the pathway and mechanism of EGCG on CRC. |
| Publish Date |
2020-05-07 05:03 |
| Citation |
Wang Y, Jin HY, Fang MZ, Wang XF, Chen H, Huang SL, Kong DS, Li M, Zhang X, Sun Y, Wang SM. Epigallocatechin gallate inhibits dimethylhydrazine-induced colorectal cancer in rats. World J Gastroenterol 2020; 26(17): 2064-2081 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i17/2064.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i17.2064 |
