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6/26/2020 10:42:52 AM | Browse: 566 | Download: 1353
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Received |
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2019-12-18 06:44 |
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Peer-Review Started |
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2019-12-18 06:48 |
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To Make the First Decision |
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Return for Revision |
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2020-02-20 05:30 |
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Revised |
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2020-03-17 06:18 |
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Second Decision |
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2020-04-08 13:32 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-04-09 00:31 |
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Articles in Press |
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2020-04-09 00:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-04-19 23:08 |
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Typeset the Manuscript |
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2020-05-25 10:05 |
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Publish the Manuscript Online |
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2020-06-25 10:09 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Cytotoxicity of nonylphenol on spermatogonial stem cells via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Hao Lei, Wen Yan, Chun-Hua Luo, Yu-Ming Guo, Yang-Yang Zhang, Xing-Huan Wang and Xin-Jun Su |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Health and Family Planning Committee Joint Fund Project of Hubei Province |
WJ2018H0020 |
| Fundamental Research Funds for the Central Universities |
2042016kf0187 |
| Health and Family Planning Committee Joint Fund Project of Hubei Province |
2042017kf0068 |
| Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund |
znpy2016022 |
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| Corresponding Author |
Xin-Jun Su, MA, Chief Doctor, Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan University, Donghu Road No. 169, Wuhan 430071, Hubei Province, China. 13697326659@139.com |
| Key Words |
Spermatogonial stem cells; Nonylphenol; Cytotoxicity; Phosphatidylinositol-3-kinase; Protein kinase B; Mammalian target of rapamycin |
| Core Tip |
With continuous advancement of industrial society, environmental pollution has become more and more serious, there has been an increase in infertility caused by environmental factors. Nonylphenol is a stable degradation product widely used in daily life and production and has been proven to affect male fertility. Our study demonstrated that nonylphenol reduced the proliferation, differentiation, and stemness maintenance of spermatogonial stem cells while promoting apoptosis and oxidative stress, and the mechanism may be related to the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway, providing a potential method for the treatment of male infertility. |
| Publish Date |
2020-06-25 10:09 |
| Citation |
Lei JH, Yan W, Luo CH, Guo YM, Zhang YY, Wang XH, Su XJ. Cytotoxicity of nonylphenol on spermatogonial stem cells via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway. World J Stem Cells 2020; 12(6): 500-513 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i6/500.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i6.500 |
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