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6/26/2020 10:42:52 AM | Browse: 39 | Download: 19
Publication Name World Journal of Stem Cells
Manuscript ID 52909
Country/Territory China
2019-12-18 06:44
Peer-Review Started
2019-12-18 06:48
To Make the First Decision
Return for Revision
2020-02-20 05:30
2020-03-17 06:18
Second Decision
2020-04-08 13:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-04-09 00:31
Articles in Press
2020-04-09 00:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-04-19 23:08
Typeset the Manuscript
2020-05-25 10:05
Publish the Manuscript Online
2020-06-25 10:09
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research and Experimental
Manuscript Type Basic Study
Article Title Cytotoxicity of nonylphenol on spermatogonial stem cells via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway
Manuscript Source Unsolicited Manuscript
All Author List Jun-Hao Lei, Wen Yan, Chun-Hua Luo, Yu-Ming Guo, Yang-Yang Zhang, Xing-Huan Wang and Xin-Jun Su
Funding Agency and Grant Number
Funding Agency Grant Number
Health and Family Planning Committee Joint Fund Project of Hubei Province WJ2018H0020
Fundamental Research Funds for the Central Universities 2042016kf0187
Health and Family Planning Committee Joint Fund Project of Hubei Province 2042017kf0068
Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund znpy2016022
Corresponding author Xin-Jun Su, MA, Chief Doctor, Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan University, Donghu Road No. 169, Wuhan 430071, Hubei Province, China. 13697326659@139.com
Keywords Spermatogonial stem cells; Nonylphenol; Cytotoxicity; Phosphatidylinositol-3-kinase; Protein kinase B; Mammalian target of rapamycin
Core Tip With continuous advancement of industrial society, environmental pollution has become more and more serious, there has been an increase in infertility caused by environmental factors. Nonylphenol is a stable degradation product widely used in daily life and production and has been proven to affect male fertility. Our study demonstrated that nonylphenol reduced the proliferation, differentiation, and stemness maintenance of spermatogonial stem cells while promoting apoptosis and oxidative stress, and the mechanism may be related to the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway, providing a potential method for the treatment of male infertility.
Publish Date 2020-06-25 10:09
Citation Lei JH, Yan W, Luo CH, Guo YM, Zhang YY, Wang XH, Su XJ. Cytotoxicity of nonylphenol on spermatogonial stem cells via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway. World J Stem Cells 2020; 12(6): 500-513
Url https://www.wjgnet.com/1948-0210/full/v12/i6/500.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i6.500
Full Article (PDF) WJSC-12-500.pdf
Full Article (Word) WJSC-12-500.docx
Manuscript File 52909-Review_Filipodia.docx
Answering Reviewers 52909-Answering reviewers.pdf
Audio Core Tip 52909-Audio core tip.mp3
Biostatistics Review Certificate 52909-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 52909-Conflict-of-interest statement.pdf
Copyright License Agreement 52909-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 52909-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 52909-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 52909-Language certificate.pdf
Peer-review Report 52909-Peer-review(s).pdf
Scientific Misconduct Check 52909-Scientific misconduct check.pdf
Scientific Editor Work List 52909-Scientific editor work list.pdf