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Publication Name World Journal of Diabetes
Manuscript ID 53265
Country/Territory France
2019-12-18 13:15
Peer-Review Started
2019-12-12 14:11
To Make the First Decision
Return for Revision
2020-01-06 22:07
2020-03-16 20:49
Second Decision
2020-03-30 15:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-03-30 21:09
Articles in Press
2020-03-30 21:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-04-07 22:40
Typeset the Manuscript
2020-05-09 03:35
Publish the Manuscript Online
2020-05-11 09:58
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology and Metabolism
Manuscript Type Basic Study
Article Title Maternal low protein diet induces persistent expression changes in metabolic genes in male rats
Manuscript Source Invited Manuscript
All Author List Allan de Oliveira Lira, José Luiz de Brito Alves, Mariana Pinheiro Fernandes, Diogo Vasconcelos, David Filipe Santana, João Henrique da Costa-Silva, Béatrice Morio, Carol Góis Leandro and Luciano Pirola
Funding Agency and Grant Number
Funding Agency Grant Number
the CAPES/COFECUB 797-14
the National Council for Research – Brazil 477915/2012-4
Corresponding author Luciano Pirola, PhD, Senior Researcher, Carmen (Cardiology, Metabolism and Nutrition) Laboratory, INSERM U1060, Lyon-1 University,South Lyon Medical Faculty Sector 2, CENS ELI-2D building, 165 Chemin du grand Revoyet, Pierre Benite 69310, France. luciano.pirola@univ-lyon1.fr
Keywords Metabolic adaptation; Phenotype plasticity; Liver; Adipose tissue; Metabolism; Maternal protein undernutrition
Core Tip Perinatal exposure to a poor nutritional environment predisposes to metabolic disease. Here, the expression of metabolism-related genes in adipose tissue and liver was investigated. We evaluated the alterations in gene expression of glycolytic/Krebs cycle genes, adipogenic and lipolitic genes in adipose tissue of offspring rats at 30/90 d of age, exposed to maternal low-protein diet throughout gestation/lactation. We also evaluated expression of liver transcription factors and gluconeogenic genes. Persistent gene alterations were observed, that may account for the metabolic adaptations in response to maternal low-protein diet, highlighting the occurrence of persistent transcriptional defects as a consequence of perinatal malnutrition.
Publish Date 2020-05-11 09:58
Citation de Oliveira Lira A, de Brito Alves JL, Pinheiro Fernandes M, Vasconcelos D, Santana DF, da Costa-Silva JH, Morio B, Góis Leandro C, Pirola L. Maternal low protein diet induces persistent expression changes in metabolic genes in male rats. World J Diabetes 2020; 11(5): 182-192
Url https://www.wjgnet.com/1948-9358/full/v11/i5/182.htm
DOI https://dx.doi.org/10.4239/wjd.v11.i5.182
Full Article (PDF) WJD-11-182.pdf
Full Article (Word) WJD-11-182.docx
Manuscript File 53265-Review-Filipodia.docx
Answering Reviewers 53265-Answering reviewers.pdf
Audio Core Tip 53265-Audio core tip.m4a
Biostatistics Review Certificate 53265-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 53265-Conflict-of-interest statement.pdf
Copyright License Agreement 53265-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 53265-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 53265-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 53265-Language certificate.pdf
Peer-review Report 53265-Peer-review(s).pdf
Scientific Misconduct Check 53265-Scientific misconduct check.pdf
Scientific Editor Work List 53265-Scientific editor work list.pdf