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7/26/2020 8:27:48 AM | Browse: 41 | Download: 37
Publication Name World Journal of Stem Cells
Manuscript ID 53270
Country/Territory China
2020-01-20 11:58
Peer-Review Started
2020-01-20 11:58
To Make the First Decision
Return for Revision
2020-03-24 15:24
2020-04-04 01:11
Second Decision
2020-05-15 10:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-17 01:38
Articles in Press
2020-05-17 01:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-05-21 23:08
Typeset the Manuscript
2020-07-20 02:43
Publish the Manuscript Online
2020-07-26 08:24
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Neurosciences
Manuscript Type Basic Study
Article Title Bone marrow mesenchymal stem cells induce M2 microglia polarization through PDGF-AA/MANF signaling
Manuscript Source Unsolicited Manuscript
All Author List Fan Yang, Wen-Bin Li, Ye-Wei Qu, Jin-Xing Gao, Yu-Shi Tang, Dong-Jie Wang and Yu-Jun Pan
Funding Agency and Grant Number
Funding Agency Grant Number
State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences SKLN-201402
State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences SKLN-201801
Foundation for Returned Overseas Chinese Scholars of Heilongjiang Province LC201040
Corresponding author Yu-Jun Pan, PhD, Chief Doctor, Professor, Department of Neurology, The First Clinical College of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang Province, China. yujunpan@ems.hrbmu.edu.cn
Keywords Mesencephalic astrocyte–derived neurotrophic factor; Bone marrow mesenchymal stem cell; Microglia/macrophage polarization; Endoplasmic reticulum stress; Cerebral ischemia/reperfusion injury;
Core Tip Induction of M2 microglia/macrophage polarization may contribute to the mechanisms underlying the neuroprotective effect of bone marrow mesenchymal stem cells (BMSCs) in treating stroke. This is one of the few known studies exploring the soluble mediators responsible for interactions between BMSCs and microglia/macrophages. We demonstrated that BMSCs-mediated MANF paracrine signaling, in particular the PDGF-AA/miR-30a*/XBP1/MANF pathway, was involved in BMSCs-induced M2 phenotype polarization. Therefore, this novel molecular mechanism of BMSCs-based immunomodulatory effect on microglia/macrophages may be a novel promising therapeutic strategy for treatment of ischemic stroke.
Publish Date 2020-07-26 08:24
Citation Yang F, Li WB, Qu YW, Gao JX, Tang YS, Wang DJ, Pan YJ. Bone marrow mesenchymal stem cells induce M2 microglia polarization through PDGF-AA/MANF signaling. World J Stem Cells 2020; 12(7): 633-658
Url https://www.wjgnet.com/1948-0210/full/v12/i7/633.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i7.633
Full Article (PDF) WJSC-12-633.pdf
Full Article (Word) WJSC-12-633.docx
Manuscript File 53270-Review_WangTQ.docx
Answering Reviewers 53270-Answering reviewers.pdf
Audio Core Tip 53270-Audio core tip.m4a
Biostatistics Review Certificate 53270-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 53270-Conflict-of-interest statement.pdf
Copyright License Agreement 53270-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 53270-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 53270-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 53270-Language certificate.pdf
Supplementary Material 53270-Supplementary material.pdf
Peer-review Report 53270-Peer-review(s).pdf
Scientific Misconduct Check 53270-Supplementary material.pdf
Scientific Editor Work List 53270-Scientific editor work list.pdf