Publication Name	World Journal of Clinical Cases
Manuscript ID	53911
Country	Türkiye

Received	2020-01-12 13:34
Peer-Review Started	2020-01-12 13:36
To Make the First Decision	2020-02-28 03:59
Return for Revision	2020-02-28 09:29
Revised	2020-03-27 10:19
Second Decision	2020-04-30 09:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-04-30 21:49
Articles in Press	2020-04-30 21:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-05-17 10:38
Publish the Manuscript Online	2020-05-25 09:57

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Prophylactic and therapeutic roles of oleanolic acid its derivatives in several diseases
Manuscript Source	Invited Manuscript
All Author List	Alaattin Sen
Funding Agency and Grant Number
Corresponding Author	Alaattin Sen, PhD, Academic Fellow, Academic Research, Chairman, Full Professor, Instructor, Research Scientist, Senior Lecturer, Senior Researcher, Senior Scientist, Department of Molecular Biology and Genetics, Faculty of Life and Natural Sciences, Abdullah Gul University, Sumer Campus, Kocasinan, Kayseri 38080, Türkiye. sena@agu.edu.tr
Key Words	Oleanolic acid; Prophylactic; Anti-inflammatory; Anti-diabetics; Neuroprotective; Hepatoprotective
Core Tip	Oleanolic acid (OA) is plentiful in many fruits and vegetables. Studies have shown that OA and its derivatives exert promising pharmacological actions including anti-inflammatory, neuroprotective, hepatoprotective, anti-osteoporotic and anti-diabetics at low doses. However, it is not a “cure-all” drug or drug candidate and could exert adverse effects at high doses, particularly its derivatives. In addition, information elucidating the drug-drug/drug-herb interactions associated with OA and its derivatives is inadequate. Nevertheless, there is a reasonable amount of literature, as fully explored in this review that OA and its derivatives have crucial prophylactic and therapeutic potential for diseases including ulcerative colitis, diabetes and cardiovascular diseases.
Publish Date	2020-05-25 09:57
Citation	Sen A. Prophylactic and therapeutic roles of oleanolic acid its derivatives in several diseases. World J Clin Cases 2020; 8(10): 1767-1792
URL	https://www.wjgnet.com/2307-8960/full/v8/i10/1767.htm
DOI	https://dx.doi.org/10.12998/wjcc.v8.i10.1767

Full Article (PDF)	WJCC-8-1767.pdf
Full Article (Word)	WJCC-8-1767.docx
Manuscript File	53911-Review.docx
Answering Reviewers	53911-Answering reviewers.pdf
Audio Core Tip	53911-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	53911-Conflict-of-interest statement.pdf
Copyright License Agreement	53911-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	53911-Language certificate.pdf
Peer-review Report	53911-Peer-review(s).pdf
Scientific Misconduct Check	53911-Scientific misconduct check.pdf
Scientific Editor Work List	53911-Scientific editor work list.pdf