| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
CR6-interacting factor-1 contributes to osteoclastogenesis by inducing receptor activator of nuclear factor κB ligand after radiation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Xin Xiang, Li Chen, Yang Xiang, Feng-Jie Li, Xiao-Mei Zhang, Yan-Ni Xiao, Ling-Yun Zou, Jiang F Zhong, Qian Ran, Shengwen Calvin Li and Zhong-Jun Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81502754 |
| National Natural Science Foundation of China (Major Program) |
31571352 |
| Interdisciplinary and International Cooperation Projects of The Second Affiliated Hospital, Third Military Medical University |
2016YXKJC0 |
|
| Corresponding Author |
Zhong-Jun Li, MD, Professor, Laboratory Medicine Center, Department of Blood Transfusion, Lab of Radiation Biology, The Second Affiliated Hospital, Third Military Medical University, Xinqiao Road, Chongqing 400037, China. johnneyusc@gmail.com |
| Key Words |
Irradiation; Osteoporosis; Bone marrow; Mesenchymal stem cells; Monocyte macrophage; Bone |
| Core Tip |
Current treatment of osteoporosis is based mainly on inhibiting bone resorption or stimulating bone generation to increase bone mass, however, the side-effects of some drugs affect long-term administration and adherence. There is still a lack of effective prevention or treatment for radiation-induced bone injury. Because of the contribution of adipocytes to osteoporosis, future drug screening should target not only the regulation of the balance between bone formation and bone resorption but also the balance between osteogenic and adipogenic differentiation. Here, through screening, we identified five CR6-interacting factor-1 inhibitors targeted CR6-interacting factor-1-protein kinase cyclic adenosine monophosphate-activited catalytic subunit alpha interaction interface that could dramatically reduce receptor activator of nuclear factor κB ligand secretion and adipogenesis. Our study provides insights into potential therapeutic strategies for radiation-induced bone injury. |
| Publish Date |
2020-03-26 03:33 |
| Citation |
Xiang LX, Ran Q, Chen L, Xiang Y, Li FJ, Zhang XM, Xiao YN, Zou LY, Zhong JF, Li SC, Li ZJ. CR6-interacting factor-1 contributes to osteoclastogenesis by inducing receptor activator of nuclear factor κB ligand after radiation. World J Stem Cells 2020; 12(3): 222-240 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i3/222.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i3.222 |
