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8/18/2020 6:51:20 AM | Browse: 565 | Download: 1302
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Received |
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2020-01-31 14:20 |
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Peer-Review Started |
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2020-01-31 14:20 |
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First Decision by Editorial Office Director |
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2020-04-29 18:48 |
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Return for Revision |
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2020-04-29 18:48 |
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Revised |
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2020-06-02 18:14 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-07-14 03:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-07-19 21:50 |
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Articles in Press |
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2020-07-19 21:50 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-08-17 04:00 |
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Publish the Manuscript Online |
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2020-08-18 02:09 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Opinion Review |
| Article Title |
Classic Ehlers-Danlos syndrome and cardiac transplantation - Is there a connection?
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Merlin G Butler |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Institute of Child Health and Human Development |
HD02528 |
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| Corresponding Author |
Merlin G Butler, MD, PhD, Professor, Department of Psychiatry and Behavioral Sciences, University of Kansas Medical Center, 3901 Rainbow Boulevard, MS 4015, Kansas City, KS 66160, United States. mbutler4@kumc.edu |
| Key Words |
Ehlers-Danlos syndrome; Next-generation sequencing; Surgical complications; Beighton hypermobility scale; Cardiac failure and transplantation; |
| Core Tip |
Ehlers-Danlos syndrome (EDS) consists of a group of connective tissue disorders involving both autosomal dominant and recessive inheritance patterns often involving collagen genes with variants readily detectable using disease-specific gene panels with next-generation sequencing. A 55 year-old male is reported with features of a connective tissue disorder. He had a heart transplant at 43 years of age. He was found to have a COL5A1 gene variant (c:605T7A; p.I1e102Asn) causing classic EDS. He is brought to medical attention for consideration of a genetic cause of cardiac failure including EDS in other patients and complications of surgery which may occur. |
| Publish Date |
2020-08-18 02:09 |
| Citation |
Butler MG. Classic Ehlers-Danlos syndrome and cardiac transplantation - Is there a connection? World J Cardiol 2020; 12(8): 368-372 |
| URL |
https://www.wjgnet.com/1949-8462/full/v12/i8/368.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v12.i8.368 |
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