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9/10/2020 7:50:29 AM | Browse: 415 | Download: 526
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Received |
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2020-03-21 09:08 |
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Peer-Review Started |
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2020-03-21 09:10 |
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To Make the First Decision |
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Return for Revision |
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2020-04-26 21:43 |
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Revised |
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2020-05-11 01:43 |
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Second Decision |
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2020-07-17 10:01 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-07-19 21:29 |
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Articles in Press |
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2020-07-19 21:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-07-24 02:53 |
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Typeset the Manuscript |
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2020-08-20 00:45 |
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Publish the Manuscript Online |
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2020-09-10 05:57 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Molecular determinants of response to 5-fluorouracil-based chemotherapy in colorectal cancer: The undisputable role of micro-ribonucleic acids
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Amirsaeed Sabeti Aghabozorgi, Mostafa Moradi Sarabi, Reza Jafarzadeh-Esfehani, Shabnaz Koochakkhani, Marziyeh Hassanzadeh, Soudabeh Kavousipour and Ebrahim Eftekhar |
| Funding Agency and Grant Number |
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| Corresponding Author |
Ebrahim Eftekhar, PhD, Associate Professor, Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Jomhori Street, Bandar Abbas 7919915519, Iran. eftekhar19@gmail.com |
| Key Words |
5-flurouracil; Colorectal cancer; Chemotherapy resistance; Thymidylate synthase; Microsatellite instability; Micro-ribonucleic acid |
| Core Tip |
Resistance to the main chemotherapy drug, 5-flurouracil (5-FU), is an important cause of failure in clinical colorectal cancer (CRC) therapy. Microsatellite instability, increased activity and expression level of thymidylate synthase and dihydropyridine dehydrogenase, mutation of TP53 as well as micro-ribonucleic acids alterations are among the main molecular determinants of response to 5-FU-based chemotherapy in CRC. The identification of potential molecular determinants of response to 5-FU could be an important clinical tool for developing treatment strategies and selecting CRC patients who are most likely to benefit from 5-FU chemotherapy. |
| Publish Date |
2020-09-10 05:57 |
| Citation |
Sabeti Aghabozorgi A, Moradi Sarabi M, Jafarzadeh-Esfehani R, Koochakkhani S, Hassanzadeh M, Kavousipour S, Eftekhar E. Molecular determinants of response to 5-fluorouracil-based chemotherapy in colorectal cancer: The undisputable role of micro-ribonucleic acids. World J Gastrointest Oncol 2020; 12(9): 942-956 |
| URL |
https://www.wjgnet.com/1948-5204/full/v12/i9/942.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v12.i9.942 |
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