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7/23/2020 7:27:52 AM | Browse: 373 | Download: 1056
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Received |
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2020-03-30 13:09 |
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Peer-Review Started |
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2020-03-30 13:22 |
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To Make the First Decision |
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Return for Revision |
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2020-04-22 16:05 |
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Revised |
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2020-06-04 21:05 |
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Second Decision |
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2020-06-10 08:55 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-06-10 19:53 |
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Articles in Press |
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2020-06-10 19:53 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-07-10 00:13 |
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Publish the Manuscript Online |
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2020-07-23 05:00 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Effect of zinc treatment on clinical outcomes in patients with liver cirrhosis: A systematic review and meta-analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Huey K Tan, Adam Streeter, Matthew E Cramp and Ashwin D Dhanda |
| Funding Agency and Grant Number |
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| Corresponding Author |
Ashwin D Dhanda, BSc, MBChB, MRCP, PhD, Associate Professor, Hepatology Research Group, Institute of Translational and Stratified Medicine, Faculty of Health, University of Plymouth, John Bull Building, Research Way, Plymouth PL6 8BU, United Kingdom. ashwin.dhanda@plymouth.ac.uk |
| Key Words |
Zinc; Cirrhosis; Mortality; ; ; |
| Core Tip |
Zinc deficiency is highly prevalent in patients with cirrhosis and may contribute to disease progression and mortality. This systematic review aimed to determine whether zinc supplementation was associated with clinical outcomes in patients with cirrhosis. Meta-analysis of data from four eligible studies found that zinc supplementation was not associated with reduced mortality at 6 mo. No study reported changes in disease severity or complications. Eligible studies were highly heterogeneous with different zinc formulations, dosage and duration applied to varying patient populations. Further well-designed prospective studies are required to determine whether zinc supplementation improves long-term clinical outcome in patients with cirrhosis. |
| Publish Date |
2020-07-23 05:00 |
| Citation |
Tan HK, Streeter A, Cramp ME, Dhanda AD. Effect of zinc treatment on clinical outcomes in patients with liver cirrhosis: A systematic review and meta-analysis. World J Hepatol 2020; 12(7): 389-398 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i7/389.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v12.i7.389 |
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