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9/1/2020 7:21:59 AM | Browse: 413 | Download: 1001
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Received |
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2020-03-28 14:51 |
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Peer-Review Started |
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2020-03-28 14:55 |
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To Make the First Decision |
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Return for Revision |
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2020-04-27 20:45 |
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Revised |
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2020-06-25 21:31 |
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Second Decision |
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2020-08-14 09:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-08-16 18:20 |
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Articles in Press |
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2020-08-16 18:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-08-29 12:28 |
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Publish the Manuscript Online |
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2020-09-01 05:06 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Role of telomere shortening in anticipation of inflammatory bowel disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Brindusa Truta, Elizabeth Wohler, Nara Sobreira, Lisa W. Datta and Steven R. Brant |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Atran Foundation |
00313651 |
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| Corresponding Author |
Brindusa Truta, MD, Assistant Professor, Division Gastroenterology & Hepatology, Johns Hopkins School of Medicine, 1830 E Monument Street, Room 426, Baltimore, MD 21210, United States. brindusa_73@yahoo.com |
| Key Words |
Inflammatory bowel disease; Telomere; Anticipation; Genetic; Inheritance; |
| Core Tip |
This is a retrospective study to evaluate the role of telomere shortening in genetic anticipation of inflammatory bowel disease (IBD). Genetic anticipation is a long disputed concept in IBD and lacks an explanatory mechanism. We analyzed generational changes in telomere length of eight parent-child pairs of three generation IBD families with anticipation and performed whole exome sequencing to identify genetic variants for autosomal inheritance. Neither telomere shortening or autosomal inheritance was associated with anticipation in our three generation IBD families, suggesting other potential mechanisms underlie this phenomenon. |
| Publish Date |
2020-09-01 05:06 |
| Citation |
Truta B, Wohler E, Sobreira N, Datta L, Brant S. Role of telomere shortening in anticipation of inflammatory bowel disease. World J Gastrointest Pharmacol Ther 2020; 11(4): 69-78 |
| URL |
https://www.wjgnet.com/2150-5349/full/v11/i4/69.htm |
| DOI |
https://dx.doi.org/10.4292/wjgpt.v11.i4.69 |
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