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10/14/2020 1:56:06 PM | Browse: 514 | Download: 962
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Received |
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2020-04-13 10:08 |
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Peer-Review Started |
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2020-04-13 10:08 |
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To Make the First Decision |
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Return for Revision |
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2020-04-26 21:08 |
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Revised |
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2020-05-24 15:52 |
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Second Decision |
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2020-08-25 08:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-08-26 04:05 |
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Articles in Press |
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2020-08-26 04:05 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-09-09 03:45 |
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Typeset the Manuscript |
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2020-10-13 00:24 |
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Publish the Manuscript Online |
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2020-10-14 13:53 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Diagnostic value of serum human epididymis protein 4 in esophageal squamous cell carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shi-Yuan Liu, Muhammad Ahsan Bilal, Jian-Hong Zhu and Shao-Min Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81602023 |
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| Corresponding Author |
Shi-Yuan Liu, MD, PhD, Associate Professor, Department of Thoracic Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xi'an 710004, Shaanxi Province, China. twinboysdoctors@163.com |
| Key Words |
Human epididymis protein 4; Esophageal squamous cell carcinoma; Diagnostic value; Histological stage; Clinicopathological characteristics; Clinical progression |
| Core Tip |
Numerous studies have demonstrated that human epididymis protein 4 (HE4), is over-expressed in various malignant tissues including ovarian, endometrial, lung, breast, pancreatic and gastric cancers. However, no study has examined the diagnostic impact of HE4 in patient with esophageal squamous cell carcinoma (ESCC) until now. In this study, we quantified serum HE4 levels via ELISA method using a non-biased database consisting of 80 ESCC patients, which were compared to a control group of 56 patients with benign esophageal disease. It was found that serum HE4 is significantly higher expressed in ESCC than in the control group, and the staining intensity is inversely correlated with the pathological T and N stage. It has been suggested that serum HE4 can have a potential role as an early diagnostic biomarker for ESCC. |
| Publish Date |
2020-10-14 13:53 |
| Citation |
Liu SY, Ahsan Bilal M, Zhu JH, Li SM. Diagnostic value of serum human epididymis protein 4 in esophageal squamous cell carcinoma. World J Gastrointest Oncol 2020; 12(10): 1167-1176 |
| URL |
https://www.wjgnet.com/1948-5204/full/v12/i10/1167.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v12.i10.1167 |
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