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9/24/2020 9:31:55 AM | Browse: 456 | Download: 874
Publication Name World Journal of Biological Chemistry
Manuscript ID 56088
Country/Territory Germany
Received
2020-04-16 13:53
Peer-Review Started
2020-04-16 13:53
To Make the First Decision
Return for Revision
2020-07-25 21:00
Revised
2020-08-01 10:42
Second Decision
2020-08-24 08:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-08-25 04:12
Articles in Press
2020-08-25 04:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-08-30 19:40
Typeset the Manuscript
2020-09-11 06:20
Publish the Manuscript Online
2020-09-24 09:16
ISSN 1949-8454 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Review
Article Title Regulation of cytochrome c oxidase contributes to health and optimal life
Manuscript Source Invited Manuscript
All Author List Bernhard Kadenbach
Funding Agency and Grant Number
Corresponding Author Bernhard Kadenbach, DSc, PhD, Emeritus Professor, Department of Chemistry/Biochemistry, Fachbereich Chemie, Philipps-Universität Marburg, Marburg D-35043, Hessen, Germany. kadenbach@staff.uni-marburg.de
Key Words Cytochrome c oxidase; Regulation of respiration; Allosteric ATP-inhibition; NDUFA4; Reversible phosphorylation; Efficiency of ATP synthesis; Dimerization of cytochrome c oxidase
Core Tip This article describes the “allosteric ATP-inhibition of cytochrome c oxidase“, which prevents in all eukaryotic cells the formation of reactive oxygen species (ROS) under resting conditions by keeping the mitochondrial membrane potential ΔΨm at low values. Under stress – via increased calcium concentrations – this mechanism is switched off, accompanied by increased rates of ATP-synthesis with decreased efficiency and formation of deleterious ROS. A hypothesis is described in which NDUFA4 changes its position from complex I to cytochrome c oxidase when the metabolic state changes from rest to the excited state under stress.
Publish Date 2020-09-24 09:16
Citation Kadenbach B. Regulation of cytochrome c oxidase contributes to health and optimal life. World J Biol Chem 2020; 11(2): 52-61
URL https://www.wjgnet.com/1949-8454/full/v11/i2/52.htm
DOI https://dx.doi.org/10.4331/wjbc.v11.i2.52
Full Article (PDF) WJBC-11-52.pdf
Full Article (Word) WJBC-11-52.docx
Manuscript File 56088-Review-Filipodia.docx
Answering Reviewers 56088-Answering reviewers.pdf
Audio Core Tip 56088-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 56088-Conflict-of-interest statement.pdf
Copyright License Agreement 56088-Copyright-License-Agreement-revision.pdf
Peer-review Report 56088-Peer-review(s).pdf
Scientific Misconduct Check 56088-CrossCheck.png
Scientific Misconduct Check 56088-Bing-Gong ZM-2.png
Scientific Misconduct Check 56088-Scientific misconduct check.pdf
Scientific Editor Work List 56088-Scientific editor work list.pdf