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8/12/2020 10:38:05 AM | Browse: 403 | Download: 835
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Received |
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2020-05-12 10:50 |
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Peer-Review Started |
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2020-05-12 10:50 |
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To Make the First Decision |
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Return for Revision |
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2020-06-15 18:38 |
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Revised |
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2020-06-20 13:53 |
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Second Decision |
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2020-07-21 09:43 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-07-26 21:40 |
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Articles in Press |
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2020-07-26 21:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-08-03 02:33 |
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Typeset the Manuscript |
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2020-08-10 06:02 |
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Publish the Manuscript Online |
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2020-08-12 09:10 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Interleukin-1 receptor antagonist enhances chemosensitivity to fluorouracil in treatment of Kras mutant colon cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan Yan, Hong-Wei Lin, Zhuo-Nan Zhuang, Ming Li and Sen Guo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Tsinghua Changgung Hospital Fund |
12015C1042 |
| Bethune-Excellent Surgery Fund |
HZB-20181119-13 |
| Chen Xiaoping Science and Technology Development Fund |
CXPJH11800004-021 |
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| Corresponding Author |
Sen Guo, PhD, Adjunct Professor, Department of General Surgery, Qilu Hospital of Shandong University, No. 107, Wenhuaxi Street, Jinan 250033, Shandong Province, China. guosen4321@163.com |
| Key Words |
Colon carcinoma; Chemotherapy; Nuclear factor kappa-B; Interleukin-1; Proliferation; Fluorouracil |
| Core Tip |
There was the feedback loop between up-regulated nuclear factor kappa-B (NF-κB) pathway and interleukin (IL)-1 which lead to the proliferation of cancer cells. Fluorouracil (5-FU), as a chemotherapy drug used to treat colon carcinoma cells, can activate the NF-κB pathway and lead to the resistance of chemotherapy. IL-1 receptor antagonist combined with 5-FU has stronger inhibitory effect on the proliferation of colon cancer cells due to the blocking of IL-1. It could provide an adjuvant chemotherapy plan for clinic and provide a theoretical basis for neoadjuvant chemotherapy. |
| Publish Date |
2020-08-12 09:10 |
| Citation |
Yan Y, Lin HW, Zhuang ZN, Li M, Guo S. Interleukin-1 receptor antagonist enhances chemosensitivity to fluorouracil in treatment of Kras mutant colon cancer. World J Gastrointest Oncol 2020; 12(8): 877-892 |
| URL |
https://www.wjgnet.com/1948-5204/full/v12/i8/877.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v12.i8.877 |
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