BPG is committed to discovery and dissemination of knowledge
Featured Articles
8/12/2020 10:38:05 AM | Browse: 632 | Download: 1664
 |
Received |
|
2020-05-12 10:50 |
|
Peer-Review Started |
|
2020-05-12 10:50 |
|
First Decision by Editorial Office Director |
|
2020-06-15 18:38 |
|
Return for Revision |
|
2020-06-15 18:38 |
|
Revised |
|
2020-06-20 13:53 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2020-07-21 09:43 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2020-07-26 21:40 |
|
Articles in Press |
|
2020-07-26 21:40 |
|
Edit the Manuscript by Language Editor |
|
2020-08-03 02:33 |
|
Typeset the Manuscript |
|
2020-08-10 06:02 |
|
Publish the Manuscript Online |
|
2020-08-12 09:10 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Interleukin-1 receptor antagonist enhances chemosensitivity to fluorouracil in treatment of Kras mutant colon cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan Yan, Hong-Wei Lin, Zhuo-Nan Zhuang, Ming Li and Sen Guo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Tsinghua Changgung Hospital Fund |
12015C1042 |
| Bethune-Excellent Surgery Fund |
HZB-20181119-13 |
| Chen Xiaoping Science and Technology Development Fund |
CXPJH11800004-021 |
|
| Corresponding Author |
Sen Guo, PhD, Adjunct Professor, Department of General Surgery, Qilu Hospital of Shandong University, No. 107, Wenhuaxi Street, Jinan 250033, Shandong Province, China. guosen4321@163.com |
| Key Words |
Colon carcinoma; Chemotherapy; Nuclear factor kappa-B; Interleukin-1; Proliferation; Fluorouracil |
| Core Tip |
There was the feedback loop between up-regulated nuclear factor kappa-B (NF-κB) pathway and interleukin (IL)-1 which lead to the proliferation of cancer cells. Fluorouracil (5-FU), as a chemotherapy drug used to treat colon carcinoma cells, can activate the NF-κB pathway and lead to the resistance of chemotherapy. IL-1 receptor antagonist combined with 5-FU has stronger inhibitory effect on the proliferation of colon cancer cells due to the blocking of IL-1. It could provide an adjuvant chemotherapy plan for clinic and provide a theoretical basis for neoadjuvant chemotherapy. |
| Publish Date |
2020-08-12 09:10 |
| Citation |
Yan Y, Lin HW, Zhuang ZN, Li M, Guo S. Interleukin-1 receptor antagonist enhances chemosensitivity to fluorouracil in treatment of Kras mutant colon cancer. World J Gastrointest Oncol 2020; 12(8): 877-892
|
| URL |
https://www.wjgnet.com/1948-5204/full/v12/i8/877.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v12.i8.877 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
