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9/4/2020 7:45:03 AM | Browse: 421 | Download: 948
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Received |
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2020-04-30 10:34 |
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Peer-Review Started |
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2020-04-30 10:35 |
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To Make the First Decision |
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Return for Revision |
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2020-06-13 02:42 |
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Revised |
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2020-06-24 20:14 |
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Second Decision |
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2020-08-19 11:03 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-08-19 18:32 |
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Articles in Press |
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2020-08-19 18:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-08-28 12:00 |
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Publish the Manuscript Online |
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2020-09-04 07:25 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Tumor microenvironment in primary liver tumors: A challenging role of natural killer cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Michela Anna Polidoro, Joanna Mikulak, Valentina Cazzetta, Ana Lleo, Domenico Mavilio, Guido Torzilli and Matteo Donadon |
| Funding Agency and Grant Number |
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| Corresponding Author |
Matteo Donadon, MD, PhD, Assistant Professor, Department of Hepatobiliary and General Surgery, Humanitas Clinical and Research Center - IRCCS, via manzoni, 56, Rozzano 20089, Milan, Italy. matteo.donadon@hunimed.eu |
| Key Words |
Primary liver cancer; Natural killer cells; Tumor microenvironment; Hepatocellular carcinoma; Intrahepatic cholangiocarcinoma; |
| Core Tip |
Natural killer (NK) cells are an important innate immune cell type with high cytotoxic activity, mainly involved in the clearance of virus-infected and tumor cells. Due to their potential anti-tumor activity, NK cells are gaining a deeper attention as a promising strategy for immune-based cancer therapy. Several studies reveal that both in hepatocellular carcinoma and intrahepatic cholangiocarcinoma, NK cells infiltrate within tumors and their high frequency was found to be related with a favorable overall survival in these patients. In this review, the authors summarize the current literature on NK cells and their role in primary liver tumors. |
| Publish Date |
2020-09-04 07:25 |
| Citation |
Polidoro MA, Mikulak J, Cazzetta V, Lleo A, Mavilio D, Torzilli G, Donadon M. Tumor microenvironment in primary liver tumors: A challenging role of natural killer cells. World J Gastroenterol 2020; 26(33): 4900-4918 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i33/4900.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i33.4900 |
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