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7/29/2020 3:59:38 AM | Browse: 553 | Download: 1499
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Received |
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2020-04-30 17:58 |
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Peer-Review Started |
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2020-04-30 17:59 |
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First Decision by Editorial Office Director |
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2020-05-15 21:32 |
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Return for Revision |
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2020-05-15 21:32 |
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Revised |
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2020-05-26 13:51 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-07-16 09:52 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-07-16 23:43 |
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Articles in Press |
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2020-07-16 23:43 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-07-27 00:32 |
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Publish the Manuscript Online |
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2020-07-28 14:46 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Karolina Lomperta, Katarzyna Jakubowska, Malgorzata Grudzinska, Luiza Kanczuga-Koda, Andrzej Wincewicz, Eva Surmacz, Stanislaw Sulkowski and Mariusz Koda |
| Funding Agency and Grant Number |
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| Corresponding Author |
Karolina Lomperta, MD, Doctor, Doctor, Department of General Pathomorphology, Medical University of Bialystok, 13 Waszyngtona Street, Bialystok 15269, Poland. karlomperta@gmail.com |
| Key Words |
Colorectal cancer; Insulin receptor substrate-1; Bax protein; Bcl-xL protein; Apoptosis; Antigen Ki-67 |
| Core Tip |
We analyzed the expressions of Insulin receptor substrate 1 (IRS-1), Bax, Bcl-xL and Ki-67 proteins in primary colorectal cancer (CRC). We found that IRS-1 expression was associated with tumor grade and histological type, and was more prevalent in more differentiated CRC. Interestingly, IRS-1 expression was significantly correlated with Bax and Bcl-xL, but not with Ki-67. We hypothesize that coexpression of IRS-1 and proapoptotic and antiapoptotic markers could result in a complex and diverse interplay characteristic for earlier stages in CRC. |
| Publish Date |
2020-07-28 14:46 |
| Citation |
Lomperta K, Jakubowska K, Grudzinska M, Kanczuga-Koda L, Wincewicz A, Surmacz E, Sulkowski S, Koda M. Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression. World J Gastroenterol 2020; 26(28): 4140-4150 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i28/4140.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i28.4140 |
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