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7/29/2020 3:59:38 AM | Browse: 29 | Download: 34
Publication Name World Journal of Gastroenterology
Manuscript ID 56453
Country/Territory Poland
Received
2020-04-30 17:58
Peer-Review Started
2020-04-30 17:59
To Make the First Decision
Return for Revision
2020-05-15 21:32
Revised
2020-05-26 13:51
Second Decision
2020-07-16 09:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-07-16 23:43
Articles in Press
2020-07-16 23:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-07-27 00:32
Publish the Manuscript Online
2020-07-28 14:46
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression
Manuscript Source Unsolicited Manuscript
All Author List Karolina Lomperta, Katarzyna Jakubowska, Malgorzata Grudzinska, Luiza Kanczuga-Koda, Andrzej Wincewicz, Eva Surmacz, Stanislaw Sulkowski and Mariusz Koda
Funding Agency and Grant Number
Corresponding author Karolina Lomperta, MD, Doctor, Department of General Pathomorphology, Medical University of Bialystok, 13 Waszyngtona Street, Bialystok 15269, Poland. karlomperta@gmail.com
Keywords Colorectal cancer; Insulin receptor substrate-1; Bax protein; Bcl-xL protein; Apoptosis; Antigen Ki-67
Core Tip We analyzed the expressions of Insulin receptor substrate 1 (IRS-1), Bax, Bcl-xL and Ki-67 proteins in primary colorectal cancer (CRC). We found that IRS-1 expression was associated with tumor grade and histological type, and was more prevalent in more differentiated CRC. Interestingly, IRS-1 expression was significantly correlated with Bax and Bcl-xL, but not with Ki-67. We hypothesize that coexpression of IRS-1 and proapoptotic and antiapoptotic markers could result in a complex and diverse interplay characteristic for earlier stages in CRC.
Publish Date 2020-07-28 14:46
Citation Lomperta K, Jakubowska K, Grudzinska M, Kanczuga-Koda L, Wincewicz A, Surmacz E, Sulkowski S, Koda M. Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression. World J Gastroenterol 2020; 26(28): 4140-4150
Url https://www.wjgnet.com/1007-9327/full/v26/i28/4140.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i28.4140
Full Article (PDF) WJG-26-4140.pdf
Full Article (Word) WJG-26-4140.docx
Manuscript File 56453-Review.docx
Answering Reviewers 56453-Answering reviewers.pdf
Audio Core Tip 56453-Audio core tip.mp3
Biostatistics Review Certificate 56453-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 56453-Conflict-of-interest statement.pdf
Copyright License Agreement 56453-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 56453-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 56453-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 56453-Language certificate.pdf
Peer-review Report 56453-Peer-review(s).pdf
Scientific Misconduct Check 56453-Bing-Yan JP-1.png
Scientific Misconduct Check 56453-Scientific misconduct check.pdf
Scientific Editor Work List 56453-Scientific editor work list.pdf