Publication Name	World Journal of Hepatology
Manuscript ID	56548
Country	United States

Received	2020-05-06 22:57
Peer-Review Started	2020-05-06 22:58
To Make the First Decision
Return for Revision	2020-05-24 21:12
Revised	2020-06-07 19:08
Second Decision	2020-07-29 08:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-08-01 21:12
Articles in Press	2020-08-01 21:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-08-12 06:33
Publish the Manuscript Online	2020-08-25 09:16

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Review: Pathogenesis of cholestatic liver diseases
Manuscript Source	Invited Manuscript
All Author List	Raquel T Yokoda and Eduardo A Rodriguez
Funding Agency and Grant Number
Corresponding Author	Eduardo A Rodriguez, FACP, MD, Assistant Professor, Department of Gastroenterology, Hepatology & Nutrition, University of Utah, 30 N 1900 E, Room 4R118, Salt Lake City, UT 84132, United States. eduardo.rodriguez@hsc.utah.edu
Key Words	Cholestasis; Cholangitis; Epigenomics; Immunogenetics; Pathogenesis; Bile acid
Core Tip	Several factors can condition bile flow derangements including environmental triggering factors, bile transport obstruction and conditions that alter bile concentration. Sustained pro inflammatory signaling associated with genetic and/or epigenetic dysregulation can condition a chronic dysfunctional state that can lead to a fibrogenic state with loss of homeostasis and sometimes malignant transformation.
Publish Date	2020-08-25 09:16
Citation	Yokoda RT, Rodriguez EA. Review: Pathogenesis of cholestatic liver diseases. World J Hepatol 2020; 12(8): 423-435
URL	https://www.wjgnet.com/1948-5182/full/v12/i8/423.htm
DOI	https://dx.doi.org/10.4254/wjh.v12.i8.423

Full Article (PDF)	WJH-12-423.pdf
Full Article (Word)	WJH-12-423.docx
Manuscript File	56548-Review.docx
Answering Reviewers	56548-Answering reviewers.pdf
Audio Core Tip	56548-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	56548-Conflict-of-interest statement.pdf
Copyright License Agreement	56548-Copyright license agreement.pdf
Peer-review Report	56548-Peer-review(s).pdf
Scientific Misconduct Check	56548-Scientific misconduct check.pdf
Scientific Editor Work List	56548-Scientific editor work list.pdf
CrossCheck Report	56548-CrossCheck report.pdf