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9/10/2020 7:50:29 AM | Browse: 63 | Download: 58
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 57305
Country/Territory Pakistan
Received
2020-06-03 07:56
Peer-Review Started
2020-06-03 07:57
To Make the First Decision
Return for Revision
2020-07-21 16:55
Revised
2020-08-03 11:00
Second Decision
2020-08-25 08:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-08-26 04:42
Articles in Press
2020-08-26 04:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-09-01 11:42
Publish the Manuscript Online
2020-09-10 05:57
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Notch signalling pathway in development of cholangiocarcinoma
Manuscript Source Unsolicited Manuscript
All Author List Bisma Rauff, Arif Malik, Yasir Ali Bhatti, Shafiq Ahmad Chudhary, Ishtiaq Qadri and Shafquat Rafiq
Funding Agency and Grant Number
Corresponding author Bisma Rauff, PhD, Assistant Professor, Institute of Molecular Biology and Biotechnology, University of Lahore, 1-Km Defence Road، Near Bhuptian Chowk, Lahore 54000, Pakistan. bisma.rauff@imbb.uol.edu.pk
Key Words Cholangicarcinoma; Notch receptors; Therapeutic targets; Notch signalling pathway; Gamma secretase inhibitor; Cholangiocytes
Core Tip In this review, we explore current findings on the Notch signalling pathway, its molecular components, its specific roles in the development and progression of cholangiocarcinma (CCA), the treatment approaches aimed at suppressing this signaling pathway, and discuss the encouraging results presented by basic science research and preclinical trials. The Notch signaling pathway is a key driver of cholangiocarcinogenesis and represents a promising therapeutic target in CCA. A wide and comprehensive understanding of the molecular mechanisms triggered by the pathway will help us explore novel therapies against CCA.
Publish Date 2020-09-10 05:57
Citation Rauff B, Malik A, Ali Y, Chudhary SA, Qadri I, Rafiq S. Notch signalling pathway in development of cholangiocarcinoma. World J Gastrointest Oncol 2020; 12(9): 957-974
Url https://www.wjgnet.com/1948-5204/full/v12/i9/957.htm
DOI https://dx.doi.org/10.4251/wjgo.v12.i9.957
Full Article (PDF) WJGO-12-957.pdf
Full Article (Word) WJGO-12-957.docx
Manuscript File 57305-Review.docx
Answering Reviewers 57305-Answering reviewers.pdf
Audio Core Tip 57305-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 57305-Conflict-of-interest statement.pdf
Copyright License Agreement 57305-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 57305-Language certificate.pdf
Peer-review Report 57305-Peer-review(s).pdf
Scientific Misconduct Check 57305-Bing-Yan JP-1.png
Scientific Editor Work List 57305-Scientific editor work list.pdf