Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	57305
Country	Pakistan

Received	2020-06-03 07:56
Peer-Review Started	2020-06-03 07:57
To Make the First Decision
Return for Revision	2020-07-21 16:55
Revised	2020-08-03 11:00
Second Decision	2020-08-25 08:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-08-26 04:42
Articles in Press	2020-08-26 04:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-09-01 11:42
Publish the Manuscript Online	2020-09-10 05:57

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Notch signalling pathway in development of cholangiocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Bisma Rauff, Arif Malik, Yasir Ali Bhatti, Shafiq Ahmad Chudhary, Ishtiaq Qadri and Shafquat Rafiq
Funding Agency and Grant Number
Corresponding Author	Bisma Rauff, PhD, Assistant Professor, Institute of Molecular Biology and Biotechnology, University of Lahore, 1-Km Defence Road، Near Bhuptian Chowk, Lahore 54000, Pakistan. bisma.rauff@imbb.uol.edu.pk
Key Words	Cholangicarcinoma; Notch receptors; Therapeutic targets; Notch signalling pathway; Gamma secretase inhibitor; Cholangiocytes
Core Tip	In this review, we explore current findings on the Notch signalling pathway, its molecular components, its specific roles in the development and progression of cholangiocarcinma (CCA), the treatment approaches aimed at suppressing this signaling pathway, and discuss the encouraging results presented by basic science research and preclinical trials. The Notch signaling pathway is a key driver of cholangiocarcinogenesis and represents a promising therapeutic target in CCA. A wide and comprehensive understanding of the molecular mechanisms triggered by the pathway will help us explore novel therapies against CCA.
Publish Date	2020-09-10 05:57
Citation	Rauff B, Malik A, Ali Y, Chudhary SA, Qadri I, Rafiq S. Notch signalling pathway in development of cholangiocarcinoma. World J Gastrointest Oncol 2020; 12(9): 957-974
URL	https://www.wjgnet.com/1948-5204/full/v12/i9/957.htm
DOI	https://dx.doi.org/10.4251/wjgo.v12.i9.957

Full Article (PDF)	WJGO-12-957.pdf
Full Article (Word)	WJGO-12-957.docx
Manuscript File	57305-Review.docx
Answering Reviewers	57305-Answering reviewers.pdf
Audio Core Tip	57305-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	57305-Conflict-of-interest statement.pdf
Copyright License Agreement	57305-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	57305-Language certificate.pdf
Peer-review Report	57305-Peer-review(s).pdf
Scientific Misconduct Check	57305-Bing-Yan JP-1.png
Scientific Editor Work List	57305-Scientific editor work list.pdf