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12/18/2020 1:41:06 PM | Browse: 261 | Download: 674
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Received |
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2020-06-15 14:06 |
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Peer-Review Started |
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2020-06-15 14:07 |
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To Make the First Decision |
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Return for Revision |
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2020-07-30 23:18 |
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Revised |
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2020-08-26 10:12 |
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Second Decision |
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2020-10-28 10:22 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-10-28 18:02 |
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Articles in Press |
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2020-10-28 18:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-11-01 21:18 |
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Typeset the Manuscript |
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2020-12-14 05:28 |
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Publish the Manuscript Online |
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2020-12-18 05:58 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Cyclin-dependent kinase inhibitors p21 and p27 function as critical regulators of liver regeneration following 90% hepatectomy in the rat
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Nicolas Moniaux, Laurence Lacaze, Adélie Gothland, Alice Deshayes, Didier Samuel and Jamila Faivre |
| Funding Agency and Grant Number |
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| Corresponding Author |
Nicolas Moniaux, PhD, Academic Research, Research Scientist, Senior Scientist, NA, INSERM, U1193, Paul-Brousse University Hospital, Hepatobiliary Centre, 12-14 Ave Paul Vaillant-Couturier, Villejuif 94800, France. nicolas.moniaux@inserm.fr |
| Key Words |
Major hepatectomy; Liver failure; Liver regeneration; Post-hepatectomy liver failure; p21; p27 |
| Core Tip |
With the current pandemic of obesity and diabetes and the chronic liver damages they cause, the outcomes of patients undergoing liver mass reduction for malignant diseases are poor. To design efficient strategies that limit the risk of post-hepatectomy liver failure, we used a rat model to clarify the causes of death after enlarged liver resection. Compared with standard 2/3 hepatectomy, enlarged resection resulted in a loss of hepatocyte functional activities and impaired regenerative capacities, which were associated with an overexpression of p21 and p27 inhibitors. The use of extracorporeal support device with p21 and p27 should be considered for the management of severe liver failure following extended hepatectomy. |
| Publish Date |
2020-12-18 05:58 |
| Citation |
Moniaux N, Lacaze L, Gothland A, Deshayes A, Samuel D, Faivre J. Cyclin-dependent kinase inhibitors p21 and p27 function as critical regulators of liver regeneration following 90% hepatectomy in the rat. World J Hepatol 2020; 12(12): 1198-1210 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i12/1198.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v12.i12.1198 |
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