Publication Name	World Journal of Gastroenterology
Manuscript ID	57548
Country	Türkiye

Received	2020-06-28 11:09
Peer-Review Started	2020-06-28 11:10
To Make the First Decision
Return for Revision	2020-07-28 21:04
Revised	2020-08-11 14:14
Second Decision	2020-09-09 11:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-09-09 22:44
Articles in Press	2020-09-09 22:44
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-09-12 20:42
Typeset the Manuscript	2020-09-25 05:17
Publish the Manuscript Online	2020-09-28 07:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Hepatitis E virus: Epidemiology, diagnosis, clinical manifestations, and treatment
Manuscript Source	Invited Manuscript
All Author List	Abdullah Tarık Aslan and Hatice Yasemin Balaban
Funding Agency and Grant Number
Corresponding Author	Hatice Yasemin Balaban, MD, Professor, Department of Gastroenterology, Hacettepe University Faculty of Medicine, Hacettepe University Sihhiye Campus, Ankara 06100, Türkiye. yhbalaban@gmail.com
Key Words	Hepatitis E; Hepatitis E virus; Extrahepatic manifestations; Zoonotic infection; Chronic hepatitis; Acute hepatitis
Core Tip	The hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide. To date, four main genotypes of the HEV infecting humans have been described. While HEV1 and HEV2 cause only acute hepatitis, HEV3 or HEV4 can become chronic in immunocompromised patients. Extrahepatic manifestations have also been defined for these genotypes. Acute infections are generally self-limiting and do not require special treatment. However, ribavirin is the drug of choice for the treatment of chronic hepatitis. Nevertheless, novel drugs are required for patients in whom ribavirin treatment fails. We herein reviewed the epidemiology, diagnosis, clinical manifestations, and treatment of HEV infections.
Publish Date	2020-09-28 07:42
Citation	Aslan AT, Balaban HY. Hepatitis E virus: Epidemiology, diagnosis, clinical manifestations, and treatment. World J Gastroenterol 2020; 26(37): 5543-5560
URL	https://www.wjgnet.com/1007-9327/full/v26/i37/5543.htm
DOI	https://dx.doi.org/10.3748/wjg.v26.i37.5543

Full Article (PDF)	WJG-26-5543.pdf
Full Article (Word)	WJG-26-5543.docx
Manuscript File	57548-Review-Filipodia.docx
Answering Reviewers	57548-Answering reviewers.pdf
Audio Core Tip	57548-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	57548-Conflict-of-interest statement.pdf
Copyright License Agreement	57548-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	57548-Language certificate.pdf
Peer-review Report	57548-Peer-review(s).pdf
Scientific Misconduct Check	57548-Bing-Yan JP-1.png
Scientific Misconduct Check	57548-Scientific misconduct check.pdf
Scientific Editor Work List	57548-Scientific editor work list.pdf