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12/4/2020 6:50:09 AM | Browse: 315 | Download: 658
Publication Name World Journal of Gastroenterology
Manuscript ID 58023
Country/Territory Japan
Received
2020-08-01 05:59
Peer-Review Started
2020-08-01 05:59
To Make the First Decision
Return for Revision
2020-09-30 02:51
Revised
2020-10-10 10:22
Second Decision
2020-11-11 09:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-11-12 22:22
Articles in Press
2020-11-12 22:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-12-02 05:54
Publish the Manuscript Online
2020-12-04 06:04
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Discovery of unique African Helicobacter pylori CagA-multimerization motif in the Dominican Republic
Manuscript Source Invited Manuscript
All Author List Takaaki Ono, Modesto Cruz, Hiroyuki Nagashima, Phawinee Subsomwong, Junko Akada, Takashi Matsumoto, Tomohisa Uchida, Rumiko Suzuki, Celso Hosking, José A Jiménez Abreu and Yoshio Yamaoka
Funding Agency and Grant Number
Funding Agency Grant Number
Grants-in-aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan 16H05191
Grants-in-aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan 221S0002
Grants-in-aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan 16H06279
Grants-in-aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan 18KK0266
Grants-in-aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan 19H03473
National Fund for Innovation and Development of Science and Technology from the Ministry of Higher Education Science and Technology of the Dominican Republic 2012-2013-2A1-65
National Fund for Innovation and Development of Science and Technology from the Ministry of Higher Education Science and Technology of the Dominican Republic 2015-3A1-182
Corresponding Author Yoshio Yamaoka, MD, PhD, Doctor, Professor, Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu 879-5593, Japan. yyamaoka@oita-u.ac.jp
Key Words Helicobacter pylori; CagA; CagA 3’ region; CagA-multimerization motif; Glu-Pro-Ile-Tyr-Ala motif; Dominican Republic
Core Tip We found the unique African (hpAfrica1-type) CagA-multimerization (CM) motif in Western-type CagA in the Dominican Republic and termed it Africa1-CM (Af1-CM). In addition, a few hpEurope strains carrying the Af1-CM motif had a significantly higher ancestral Africa1 component than those without the Af1-CM motif. This result suggests that the ancestors of these hpEurope strains having the Af1-CM motif underwent genetic recombination with the hpAfrica1 strains in the past. In contrast, there was no significant association between the CM motif patterns and histological scores and clinical outcomes.
Publish Date 2020-12-04 06:04
Citation Ono T, Cruz M, Nagashima H, Subsomwong P, Akada J, Matsumoto T, Uchida T, Suzuki R, Hosking C, Jiménez Abreu JA, Yamaoka Y. Discovery of unique African Helicobacter pylori CagA-multimerization motif in the Dominican Republic. World J Gastroenterol 2020; 26(45): 7118-7130
URL https://www.wjgnet.com/1007-9327/full/v26/i45/7118.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i45.7118
Full Article (PDF) WJG-26-7118.pdf
Full Article (Word) WJG-26-7118.docx
Manuscript File 58023_Auto_Edited.docx
Answering Reviewers 58023-Answering reviewers.pdf
Audio Core Tip 58023-Audio core tip.mp3
Biostatistics Review Certificate 58023-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 58023-Conflict-of-interest statement.pdf
Copyright License Agreement 58023-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 58023-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 58023-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 58023-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 58023-Language certificate.pdf
Supplementary Material 58023-Supplementary material.pdf
Peer-review Report 58023-Peer-review(s).pdf
Scientific Misconduct Check 58023-Scientific misconduct check.pdf
Scientific Editor Work List 58023-Scientific editor work list.pdf