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12/19/2020 4:10:05 PM | Browse: 497 | Download: 1488
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Received |
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2020-07-13 02:36 |
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Peer-Review Started |
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2020-07-13 02:37 |
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First Decision by Editorial Office Director |
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2020-09-30 03:30 |
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Return for Revision |
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2020-09-30 05:13 |
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Revised |
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2020-10-13 00:16 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-10-27 12:02 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-11-02 04:24 |
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Articles in Press |
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2020-11-02 04:24 |
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Edit the Manuscript by Language Editor |
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2020-11-07 20:41 |
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Typeset the Manuscript |
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2020-12-10 02:25 |
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Publish the Manuscript Online |
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2020-12-19 16:08 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Role of gut microbiome in regulating the effectiveness of metformin in reducing colorectal cancer in type 2 diabetes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qi-You Huang, Fei Yao, Chuan-Ren Zhou, Xiao-Ying Huang, Qiang Wang, Hui Long and Qing-Ming Wu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81573239 |
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| Corresponding Author |
Qing-Ming Wu, MD, PhD, Chief Doctor, Professor, Institute of Infection, Immunology and Tumor Microenvironment, Medical College, Wuhan University of Science and Technology, No. 2 Huangjiahu West Road, Baishazhou Avenue, Hongshan District, Wuhan 430065, Hubei Province, China. wuhe9224@sina.com |
| Key Words |
Metformin; Colorectal cancer; Gut microbiota; Type 2 diabetes mellitus; ; |
| Core Tip |
Metformin has been found to reduce colorectal cancer (CRC) in patients with Type 2 diabetes, but the mechanism has been unknown. Studies have confirmed that gut microbiota is not only closely related to Type 2 diabetes and CRC, but also mediates the effects of metformin. Therefore, we proposed firstly the concept of metformin-gut microbiota-CRC axis in Type 2 diabetes mellitus. The concept also provides new ideas for clinical drug use, clinical cancer treatment and clinical application of gut microbiota. |
| Publish Date |
2020-12-19 16:08 |
| Citation |
Huang QY, Yao F, Zhou CR, Huang XY, Wang Q, Long H, Wu QM. Role of gut microbiome in regulating the effectiveness of metformin in reducing colorectal cancer in type 2 diabetes. World J Clin Cases 2020; 8(24): 6213-6228 |
| URL |
https://www.wjgnet.com/2307-8960/full/v8/i24/6213.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v8.i24.6213 |
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