| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Retrospective Study |
| Article Title |
Early tacrolimus exposure does not impact long-term outcomes after liver transplantation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mikel Gastaca, Patricia Ruiz, Javier Bustamante, Lorea Martinez-Indart, Alberto Ventoso, José Ramón Fernandez, Ibone Palomares, Mikel Prieto, Milagros Testillano, Patricia Salvador, Maria Senosiain, Maria Jesus Suárez and Andres Valdivieso |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Mikel Gastaca, MD, Associate Professor, Surgeon, Department of HPB Surgery and Liver Transplantation Unit, Hospital Universitario Cruces, PLaza de Cruces s/n, Bilbao 48903, Spain. mikelgastaca@gmail.com |
| Key Words |
Liver transplantation; Tacrolimus levels; Prolonged released tacrolimus; Once-daily tacrolimus; Renal function; Survival; Outcomes |
| Core Tip |
This is a retrospective study to evaluate the effect of early tacrolimus trough levels (TTL) on the long-term outcomes after liver transplantation. Patients were classified into 2 groups according to mean TTL within the first month: ≤ 10 (n = 98) and > 10 ng/mL (n = 57). After a median follow-up of 52.8 mo (range 2.8-81.1), no significant differences were observed in: Mean estimated glomerular filtration rate, hepatocellular carcinoma recurrence, de novo tumors, biopsy-proven acute rejection rate and five-year patient and graft survival. Differences in tacrolimus levels within the first month after liver transplant did not result in significant differences in long-term outcomes. |
| Publish Date |
2021-03-20 02:13 |
| Citation |
Gastaca M, Ruiz P, Bustamante J, Martinez-Indart L, Ventoso A, Fernandez JR, Palomares I, Prieto M, Testillano M, Salvador P, Senosiain M, Suárez MJ, Valdivieso A. Early tacrolimus exposure does not impact long-term outcomes after liver transplantation. World J Hepatol 2021; 13(3): 362-374 |
| URL |
https://www.wjgnet.com/1948-5182/full/v13/i3/362.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v13.i3.362 |
