BPG is committed to discovery and dissemination of knowledge
Featured Articles
11/27/2020 9:30:55 AM | Browse: 329 | Download: 640
Publication Name World Journal of Gastroenterology
Manuscript ID 58370
Country/Territory Brazil
Received
2020-07-23 01:08
Peer-Review Started
2020-07-21 22:35
To Make the First Decision
Return for Revision
2020-10-18 13:27
Revised
2020-11-05 22:12
Second Decision
2020-11-13 10:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-11-14 04:39
Articles in Press
2020-11-14 04:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-11-25 07:32
Publish the Manuscript Online
2020-11-27 09:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Active tuberculosis in inflammatory bowel disease patients under treatment from an endemic area in Latin America
Manuscript Source Unsolicited Manuscript
All Author List Flora Maria Lorenzo Fortes, Ney Boa Sorte, Victor D Mariano, Laíla D Andrade, Fernanda A Oliveira, Monique CA Santos, Cláudia Ivanilda N dos Santos, Catharina A Passos, Mila P Pacheco, Valdiana C Surlo, Neogélia P de Almeida, Jaciane AM Fontes, Andréa M Pimentel, Raquel Rocha and Genoile Oliveira Santana
Funding Agency and Grant Number
Corresponding Author Raquel Rocha, DSc, MSc, Assistant Professor, Department of Sciences of Nutrition, School of Nutrition, Federal University of Bahia, Avenida Araújo Pinho, 32, Canela, Salvador 41701-035, BA, Brazil. raquelrocha2@yahoo.com.br
Key Words Inflammatory bowel disease; Therapy; Tumor necrosis factor alpha; Relative risk; Tuberculosis; Latent tuberculosis
Core Tip We evaluated the relative risk of developing active tuberculosis in patients receiving treatment for inflammatory bowel disease. A total of 301 patients with inflammatory bowel disease were evaluated, and an interview was conducted using a standard questionnaire and a review of the medical record. We identified the treatment during the diagnosis of active tuberculosis and the screening and past treatment for latent tuberculosis. Immunosuppressive therapy, specifically azathioprine, anti-tumor necrosis factor alpha (TNFα) and the combination of these two drugs, was associated with an increased risk of active tuberculosis. When adjusted for sex, age, type of inflammatory bowel disease (IBD) and latent tuberculosis, anti-TNFα with azathioprine consistently increased the relative risk to 17.8 times more than conventional treatment. This report is the first study in Latin America to assess the relative risk of developing active tuberculosis in patients with IBD undergoing treatment.
Publish Date 2020-11-27 09:27
Citation Fortes FML, Boa Sorte N, Mariano VD, Andrade LD, Oliveira FA, Santos MCA, dos Santos CIN, Passos CA, Pacheco MP, Surlo VC, de Almeida NP, Fontes JAM, Pimentel AM, Rocha R, Santana GO. Active tuberculosis in inflammatory bowel disease patients under treatment from an endemic area in Latin America. World J Gastroenterol 2020; 26(44): 6993-7004
URL https://www.wjgnet.com/1007-9327/full/v26/i44/6993.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i44.6993
Full Article (PDF) WJG-26-6993.pdf
Full Article (Word) WJG-26-6993.docx
STROBE Statement 58370-STROBE-Statement-revision.docx
Manuscript File 58370_Auto_Edited.docx
Answering Reviewers 58370-Answering reviewers.pdf
Audio Core Tip 58370-Audio core tip.mp4
Biostatistics Review Certificate 58370-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 58370-Conflict-of-interest statement.pdf
Copyright License Agreement 58370-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 58370-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 58370-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 58370-Language certificate.pdf
Peer-review Report 58370-Peer-review(s).pdf
Scientific Misconduct Check 58370-Bing-Yan JP-1.png
Scientific Misconduct Check 58370-Scientific misconduct check.pdf
Scientific Editor Work List 58370-Scientific editor work list.pdf