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2/24/2021 3:30:27 AM | Browse: 389 | Download: 885
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Received |
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2020-07-31 02:50 |
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Peer-Review Started |
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2020-07-31 02:51 |
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2020-10-21 19:59 |
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Revised |
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2020-10-31 12:39 |
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Second Decision |
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2020-11-11 09:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-11-12 17:04 |
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Articles in Press |
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2020-11-12 17:04 |
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Edit the Manuscript by Language Editor |
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2020-11-30 23:58 |
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Typeset the Manuscript |
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2021-02-22 06:20 |
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Publish the Manuscript Online |
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2021-02-24 03:29 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Prior transfusion of umbilical cord mesenchymal stem cells can effectively alleviate symptoms of motion sickness in mice through interleukin 10 secretion
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hua-Su Zhu, Dong Li, Cong Li, Jin-Xian Huang, Shan-Shan Chen, Lan-Bo Li, Qing Shi and Xiu-Li Ju |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Department of Science & Technology of Shandong Province |
ZR2018MH012 |
| Quancheng Industrial Leader Project |
2017018 |
| Ji'nan Science and Technology Development Foundation |
201704066 |
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| Corresponding Author |
Xiu-Li Ju, PhD, Doctor, Department of Pediatrics, Qilu Hospital of Shandong University, No. 107 Wenhua West Road, Jinan 250012, Shandong Province, China. jxlqlyy@163.com |
| Key Words |
Mesenchymal stem cell; Motion sickness; Inflammation; Immune microenvironment; Interleukin 10; JAK2/STAT3 |
| Core Tip |
This study demonstrated that prophylactic transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) can alleviate motion sickness (MS) in mice, particularly 3-5 d after transplantation. After the MS model was established, molecular biology experiments confirmed the upregulation of interleukin 10 (IL-10) in the cochlea tissues. The transplanted UC-MSCs have activated the JAK2/STAT3 signaling pathway. They reduced the sensitivity of the vestibular cortex to imbalanced movements by secreting IL-10. Accordingly, MSC transplantation is expected to be a new strategy for the prevention and treatment of MS. |
| Publish Date |
2021-02-24 03:29 |
| Citation |
Zhu HS, Li D, Li C, Huang JX, Chen SS, Li LB, Shi Q, Ju XL. Prior transfusion of umbilical cord mesenchymal stem cells can effectively alleviate symptoms of motion sickness in mice through interleukin 10 secretion. World J Stem Cells 2021; 13(2): 177-192 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i2/177.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i2.177 |
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