Publication Name	World Journal of Diabetes
Manuscript ID	58638
Country	France

Received	2020-08-03 11:50
Peer-Review Started	2020-07-31 13:10
To Make the First Decision
Return for Revision	2020-09-24 16:42
Revised	2020-09-29 07:54
Second Decision	2020-10-16 09:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-10-19 20:17
Articles in Press	2020-10-19 20:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-10-27 01:28
Typeset the Manuscript	2020-12-02 05:52
Publish the Manuscript Online	2020-12-13 05:45

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Effects of ketogenic diet and ketone bodies on the cardiovascular system: Concentration matters
Manuscript Source	Invited Manuscript
All Author List	Souad Nasser, Varvara Vialichka, Marta Biesiekierska, Aneta Balcerczyk and Luciano Pirola
Funding Agency and Grant Number	Funding Agency Grant Number Polish National Science Centre, Project Grant NCN Harmonia 2019/30/M/NZ3/00682 NAWA/Campusfrance Polonium PPN/X/RJ/1876/2019
Corresponding Author	Luciano Pirola, PhD, Senior Scientist, Carmen Laboratory, INSERM Unit 1060—Lyon 1 University, CENS ELI-2D Building, 165 Chemin du Grand Revoyet, Pierre Benite 69310, France. luciano.pirola@univ-lyon1.fr
Key Words	Endothelial cells; Ketone bodies; Vascular physiology; β-Hydroxybutyrate; β-Hydroxybutyrylation; Histone post-translational modifications
Core Tip	Ketone bodies, acting as fuel molecules, signaling molecules and epigenetic regulators, improve metabolic health and lifespan. The endothelium and the vascular system are central regulators of the organism’s metabolic state, and become dysfunctional in cardiovascular disease and diabetic complications. While in diabetic ketoacidosis high ketone bodies concentrations are detrimental to the vasculature, ketone bodies in the low-millimolar range may exert beneficial effects on the vascular system. At low concentrations, ketone bodies may prove beneficial to ameliorate vascular function and alleviate cardiovascular disease.
Publish Date	2020-12-13 05:45
Citation	Nasser S, Vialichka V, Biesiekierska M, Balcerczyk A, Pirola L. Effects of ketogenic diet and ketone bodies on the cardiovascular system: Concentration matters. World J Diabetes 2020; 11(12): 584-595
URL	https://www.wjgnet.com/1948-9358/full/v11/i12/584.htm
DOI	https://dx.doi.org/10.4239/wjd.v11.i12.584

Full Article (PDF)	WJD-11-584.pdf
Full Article (Word)	WJD-11-584.docx
Manuscript File	58638-Review-Filipodia.docx
Answering Reviewers	58638-Answering reviewers.pdf
Audio Core Tip	58638-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	58638-Conflict-of-interest statement.pdf
Copyright License Agreement	58638-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	58638-Grant application form(s).pdf
Peer-review Report	58638-Peer-review(s).pdf
Scientific Misconduct Check	58638-Scientific misconduct check.pdf
Scientific Editor Work List	58638-Scientific editor work list.pdf