Publication Name	World Journal of Gastroenterology
Manuscript ID	58930
Country	Canada

Received	2020-08-14 22:35
Peer-Review Started	2020-08-14 22:35
To Make the First Decision
Return for Revision	2020-08-22 03:45
Revised	2020-09-03 18:51
Second Decision	2020-09-16 12:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-09-17 04:49
Articles in Press	2020-09-17 04:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-10-14 00:53
Publish the Manuscript Online	2020-10-14 11:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Simmone D'souza, Keith CK Lau, Carla S Coffin and Trushar R Patel
Funding Agency and Grant Number	Funding Agency Grant Number Canada Research Chair program Alberta Innovates Strategic Research Projects G2018000880 Calgary Clinical Research Fund Pilot CRF18-0704
Corresponding Author	Trushar R Patel, PhD, Associate Professor, Department of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, 4401 University Drive West, Lethbridge T1K3M4, AB, Canada. trushar.patel@uleth.ca
Key Words	Chronic viral infection; Hallmarks of cancer; Hepatocellular carcinoma; Hepatitis B virus; Hepatitis C virus; Hepatitis delta virus co-infection
Core Tip	Hepatocellular carcinoma is a dreaded complication of viral infection with hepatitis B virus and/or hepatitis delta virus and hepatitis C virus. Many of the direct and indirect molecular mechanisms used by these viruses to co-opt the liver microenvironment for persistence also disrupt cell cycle pathways. Indirectly, the immune system has a major role in the contribution of hepatocellular carcinoma in the context of viral hepatitis, but direct viral mechanisms also create a pro-tumorigenic environment.
Publish Date	2020-10-14 11:33
Citation	D'souza S, Lau KC, Coffin CS, Patel TR. Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma. World J Gastroenterol 2020; 26(38): 5759-5783
URL	https://www.wjgnet.com/1007-9327/full/v26/i38/5759.htm
DOI	https://dx.doi.org/10.3748/wjg.v26.i38.5759

Full Article (PDF)	WJG-26-5759.pdf
Full Article (Word)	WJG-26-5759.docx
Manuscript File	58930-Review.docx
Answering Reviewers	58930-Answering reviewers.pdf
Audio Core Tip	58930-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	58930-Conflict-of-interest statement.pdf
Copyright License Agreement	58930-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	58930-Grant application form(s).pdf
Peer-review Report	58930-Peer review.pdf
Scientific Misconduct Check	58930-Bing-Yan JP-1.png
Scientific Misconduct Check	58930-Scientific misconduct check.pdf
Scientific Editor Work List	58930-Scientific editor work list.pdf