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2/1/2021 1:37:33 PM | Browse: 405 | Download: 726
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 59071
Country/Territory Slovenia
Received
2020-09-27 12:21
Peer-Review Started
2020-09-27 12:21
To Make the First Decision
Return for Revision
2020-12-12 18:36
Revised
2020-12-22 11:35
Second Decision
2021-01-05 02:50
Accepted by Journal Editor-in-Chief
2021-01-06 04:01
Accepted by Company Editor-in-Chief
2021-01-07 20:20
Articles in Press
2021-01-07 20:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-01-28 07:10
Publish the Manuscript Online
2021-02-01 11:01
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Clinical and Translational Research
Article Title Total neoadjuvant therapy vs standard therapy of locally advanced rectal cancer with high-risk factors for failure
Manuscript Source Unsolicited Manuscript
All Author List Mojca Tuta, Nina Boc, Erik Brecelj, Monika Peternel and Vaneja Velenik
Funding Agency and Grant Number
Corresponding Author Vaneja Velenik, MD, PhD, Associate Professor, Division of Radiotherapy, Institute of Oncology, Zaloška cesta 2, Ljubljana 1000, Slovenia. vvelenik@onko-i.si
Key Words Locally advanced rectal cancer; Total neoadjuvant therapy; Pathological complete response; Neoadjuvant rectal cancer score
Core Tip Our data suggest that treatment of locally advanced rectal cancer (LARC) with high-risk factors for failure using total neoadjuvant therapy (TNT) is more effective than standard therapy, achieving a higher rate of pathological complete response, more favourable survival prognosis, higher proportion of T-and N-downstaging, shorter time to temporary stoma closure, better compliance, and lower toxicity grade 3-5 during systemic chemotherapy. The outcomes of TNT in patients with the most aggressive form of LARC are completely comparable to TNT in all patients with LARC.
Publish Date 2021-02-01 11:01
Citation Tuta M, Boc N, Brecelj E, Peternel M, Velenik V. Total neoadjuvant therapy vs standard therapy of locally advanced rectal cancer with high-risk factors for failure. World J Gastrointest Oncol 2021; 13(2): 119-130
URL https://www.wjgnet.com/1948-5204/full/v13/i2/119.htm
DOI https://dx.doi.org/10.4251/wjgo.v13.i2.119
Full Article (PDF) WJGO-13-119.pdf
Full Article (Word) WJGO-13-119.docx
Manuscript File 59071_Auto_Edited.docx
Answering Reviewers 59071-Answering reviewers.pdf
Audio Core Tip 59071-Audio core tip.mp3
Biostatistics Review Certificate 59071-Biostatistics statement.pdf
Clinical Trial Registration Statement 59071-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 59071-Conflict-of-interest statement.pdf
Copyright License Agreement 59071-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 59071-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 59071-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 59071-Language certificate.pdf
Peer-review Report 59071-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 59071-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 59071-Bing-Yan JP-1.png
Scientific Misconduct Check 59071-Scientific misconduct check.pdf
Scientific Editor Work List 59071-Scientific editor work list.pdf