| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Long non-coding ribonucleic acid W5 inhibits progression and predicts favorable prognosis in hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Guang-Lin Lei, Hong-Xia Fan, Cheng Wang, Yan Niu, Tie-Ling Li, Ling-Xiang Yu, Zhi-Xian Hong, Jin Yan, Xi-Liang Wang, Shao-Geng Zhang, Ming-Ji Ren and Peng-Hui Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Natural Science Foundation of Beijing, China |
7202194 |
| the Natural Science Foundation of Beijing, China |
7162185 |
|
| Corresponding Author |
Peng-Hui Yang, MD, Professor, Fifth Medical Center of Chinese PLA General Hospital, /, No. 100 Xisihuan Zhong Lu, Fengtai District, Beijing 100039, China. yph3022017@163.com |
| Key Words |
Hepatocellular carcinoma; Long non-coding ribonucleic acid; Long non-coding ribonucleic acid W5 |
| Core Tip |
Our results showed that the expression of long non-coding ribonucleic acids (lncRNAs) W5 was considerably reduced in hepatocellular carcinoma (HCC) tissues, which suppressed proliferation, migration and invasion of tumor cells in vitro. Our study also showed that low expression of lncRNA W5 correlated tumor progression and poor prognosis. Furthermore, manipulations of lncRNA W5 expression impacted on HCC biological behaviors. These results suggest that lncRNA W5 may serve as a tumor suppressor in the development and progression of HCC, and have a potential to be a diagnostic and therapeutic target in the clinical management of HCC. |
| Publish Date |
2020-12-30 13:59 |
| Citation |
Lei GL, Fan HX, Wang C, Niu Y, Li TL, Yu LX, Hong ZX, Yan J, Wang XL, Zhang SG, Ren MJ, Yang PH. Long non-coding ribonucleic acid W5 inhibits progression and predicts favorable prognosis in hepatocellular carcinoma. World J Gastroenterol 2021; 27(1): 55-68 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i1/55.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i1.55 |
