BPG is committed to discovery and dissemination of knowledge
Featured Articles
3/25/2021 6:37:30 AM | Browse: 419 | Download: 616
Publication Name World Journal of Stem Cells
Manuscript ID 59128
Country/Territory China
Received
2020-08-29 04:01
Peer-Review Started
2020-08-29 04:01
To Make the First Decision
Return for Revision
2021-01-07 19:24
Revised
2021-01-19 03:24
Second Decision
2021-01-29 06:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-02-26 03:26
Articles in Press
2021-02-26 03:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-03-08 04:28
Typeset the Manuscript
2021-03-24 06:11
Publish the Manuscript Online
2021-03-25 06:36
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Review
Article Title Functional maturation of immature β cells: A roadblock for a stem cell therapy to type 1 diabetes
Manuscript Source Invited Manuscript
All Author List Zi-Yi Sun, Ting-Yan Yu, Fang-Xu Jiang and Wei Wang
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of China 81471081
Natural Science Foundation of Fujian Province, China 2019J01010
Xiamen Research Foundation for Science and Technology Project 3502Z20194037
Scientific Research Foundation for Advanced Talents, Xiang’an Hospital of Xiamen University PM201809170005
Corresponding Author Wei Wang, MD, Doctor, Department of Endocrinology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, 2000 Xiang'an East Road, Xiang'an District, Xiamen 361101, Fujian , China. wwei19742007@hotmail.com
Key Words Stem cell therapy; Type 1 diabetes mellitus; β cell; Maturation
Core Tip Type 1 diabetes is a metabolic disease characterized by absolute lack of insulin. Current insulin replacement therapy supplies insulin in a non-physiological way and is associated with devastating complications. A diabetes stem cell therapy with insulin-producing β-like cells differentiated in vitro from human pluripotent stem cells has recently attracted great interest in the academic community and the general public. Though great progresses have been made, the β-like cells differentiated in vitro differentiation still have many defects. Here we summarize the latest knowledge on β-cell maturation in vivo and in vitro and the vital roles of key molecules in this process, in order to explore the current problems in a diabetes stem cell therapy.
Publish Date 2021-03-25 06:36
Citation Sun ZY, Yu TY, Jiang FX, Wang W. Functional maturation of immature β cells: A roadblock for a stem cell therapy to type 1 diabetes. World J Stem Cells 2021; 13(3): 193-207
URL https://www.wjgnet.com/1948-0210/full/v13/i3/193.htm
DOI https://dx.doi.org/10.4252/wjsc.v13.i3.193
Full Article (PDF) WJSC-13-193.pdf
Full Article (Word) WJSC-13-193.docx
Manuscript File 59128_Auto_Edited_LM_WangTQ.docx
Answering Reviewers 59128-Answering reviewers.pdf
Audio Core Tip 59128-Audio core tip.wav
Conflict-of-Interest Disclosure Form 59128-Conflict-of-interest statement.pdf
Copyright License Agreement 59128-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 59128-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 59128-Language certificate.pdf
Peer-review Report 59128-Peer-review(s).pdf
Scientific Misconduct Check 59128-Bing-Wang JL-1.jpg
Scientific Misconduct Check 59128-Scientific misconduct check.pdf
Scientific Editor Work List 59128-Scientific editor work list.pdf