Publication Name	World Journal of Gastroenterology
Manuscript ID	59172
Country	Japan

Received	2020-08-28 18:02
Peer-Review Started	2020-08-28 18:02
First Decision by Editorial Office Director	2020-11-03 14:57
Return for Revision	2020-11-03 14:57
Revised	2020-11-17 10:43
Publication Fee Transferred
Second Decision by Editor	2020-12-29 02:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2020-12-29 19:31
Articles in Press	2020-12-29 19:31
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-01-21 05:15
Publish the Manuscript Online	2021-02-20 02:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Translational Research
Article Title	Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort
Manuscript Source	Unsolicited Manuscript
All Author List	Kento Imajo, Louise Tetlow, Andrea Dennis, Elizabeth Shumbayawonda, Sofia Mouchti, Timothy J Kendall, Eve Fryer, Shogi Yamanaka, Yasushi Honda, Takaomi Kessoku, Yuji Ogawa, Masato Yoneda, Satoru Saito, Catherine Kelly, Matt D Kelly, Rajarshi Banerjee and Atsushi Nakajima
Funding Agency and Grant Number
Corresponding Author	Andrea Dennis, PhD, Research Scientist, Innovation, Perspectum, Gemini One, 5520 John Smith Drive, Oxford OX4 2LL, United Kingdom. andrea.dennis@perspectum.com
Key Words	Corrected T1; Fibro-inflammation; Non-invasive imaging; Non-alcoholic steatohepatitis; Multiparametric magnetic resonance imaging; Non-alcoholic fatty liver disease
Core Tip	There is growing interest in the utility of non-invasive tests in the management of non-alcoholic steatohepatitis or non-alcoholic steatohepatitis (NASH). We explored how magnetic resonance imaging technology can stratify patients with simple fatty liver disease from those with NASH. Our results showed that quantitative magnetic resonance imaging derived metrics showed the strong correlations to the histological pathological components of NASH with very few technical failures. We also observed very high levels of inter-reader disagreement in histopathological biopsy reads, highlighting the pressing need for alternative diagnostic tests for NASH. Our work therefore supports the use this non-invasive technology in day-to-day practice.
Publish Date	2021-02-20 02:51
Citation	Imajo K, Tetlow L, Dennis AM, Shumbayawonda E, Mouchti S, Kendall TJ, Fryer E, Yamanaka S, Honda Y, Kessoku T, Ogawa Y, Yoneda M, Saito S, Kelly C, Kelly MD, Banerjee R, Nakajima A. Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort. World J Gastroenterol 2021; 27(7): 609-623
URL	https://www.wjgnet.com/1007-9327/full/v27/i7/609.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i7.609

Full Article (PDF)	WJG-27-609.pdf
Full Article (Word)	WJG-27-609.docx