BPG is committed to discovery and dissemination of knowledge
Featured Articles
2/6/2021 12:29:51 PM | Browse: 48 | Download: 55
Publication Name World Journal of Clinical Cases
Manuscript ID 59730
Country/Territory Germany
Received
2020-09-24 15:56
Peer-Review Started
2020-09-24 15:57
To Make the First Decision
Return for Revision
2020-12-08 08:16
Revised
2020-12-08 09:05
Second Decision
2020-12-17 12:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-12-23 05:01
Articles in Press
2020-12-23 05:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-01-21 02:06
Publish the Manuscript Online
2021-02-06 11:08
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Case Report
Article Title Wilson disease — the impact of hyperimmunity on disease activity: A case report
Manuscript Source Unsolicited Manuscript
All Author List Wolfgang Stremmel, Thomas Longerich, René Liere, Vladimir Vacata, Josef van Helden and Ralf Weiskirchen
Funding Agency and Grant Number
Corresponding Author Wolfgang Stremmel, MD, Senior Scientist, Department of Gastroenterology and Hepatology, Medical Center Baden-Baden, Im Neuenheimer Feld 410, Baden-Baden D-76530, Germany. wolfgangstremmel@aol.com
Key Words Wilson disease; Copper metabolism; Antinuclear antibodies; Diagnosis; Steroid therapy; Case report
Core Tip Variable courses of metabolic liver diseases remain obscure. A 9-year-old girl with Wilson disease had concomitant antinuclear antibodies elevation without immunoglobulin G elevation. Already after one year of therapy with copper chelators the free copper as treatment target was normalized as well as transaminases. Six years later transaminases (alanine aminotransferase) rose despite normalized free copper up to 571 U/L in December 2019. A short-term steroid therapy, improved transaminases significantly. As underlying course, such a neglected hyperimmune state without immunoglobulin elevation was verified in a cohort of 5.789 liver disease patients and may represent a new entity explaining liver disease activation.
Publish Date 2021-02-06 11:08
Citation Stremmel W, Longerich T, Liere R, Vacata V, van Helden J, Weiskirchen R. Wilson disease — the impact of hyperimmunity on disease activity: A case report. World J Clin Cases 2021; 9(6): 1386-1393
Url https://www.wjgnet.com/2307-8960/full/v9/i6/1386.htm
DOI https://dx.doi.org/10.12998/wjcc.v9.i6.1386
Full Article (PDF) WJCC-9-1386.pdf
Full Article (Word) WJCC-9-1386.docx
Manuscript File 59730_Auto_Edited.docx
Answering Reviewers 59730-Answering reviewers.pdf
Audio Core Tip 59730-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 59730-Conflict-of-interest statement.pdf
Copyright License Agreement 59730-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 59730-Informed consent statement.pdf
Peer-review Report 59730-Peer-review(s).pdf
Scientific Misconduct Check 59730-Bing-Yan JP-1.png
Scientific Misconduct Check 59730-Scientific misconduct check.pdf
Scientific Editor Work List 59730-Scientific editor work list.pdf