Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	59899
Country	Ecuador

Received	2020-10-06 19:35
Peer-Review Started	2020-10-06 19:36
To Make the First Decision
Return for Revision	2020-12-01 17:50
Revised	2020-12-09 18:45
Second Decision	2020-12-15 08:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-12-17 00:54
Articles in Press	2020-12-17 00:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-01-08 02:46
Publish the Manuscript Online	2021-01-10 12:31

ISSN	1948-5190 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Cost-effectiveness of endoscopic ultrasound-guided coils plus cyanoacrylate injection compared to endoscopic cyanoacrylate injection in the management of gastric varices
Manuscript Source	Unsolicited Manuscript
All Author List	Carlos Robles-Medranda, Joao Autran Nebel, Miguel Puga-Tejada, Roberto Oleas, Jorge Baquerizo-Burgos, Jesenia Ospina-Arboleda, Manuel Valero and Hannah Pitanga-Lukashok
Funding Agency and Grant Number
Corresponding Author	Carlos Robles-Medranda, MD, Chief Doctor, Gastroenterology and Endoscopy Division, Instituto Ecuatoriano de Enfermedades Digestivas (IECED), Av. Abel Romeo Castillo y Av. Juan Tanca Marengo, Torre Vitalis, Mezzanine 3, Guayaquil 090505, Guayas, Ecuador. carlosoakm@yahoo.es
Key Words	Cost-effectiveness; Endoscopic ultrasound-guided therapy; Gastric varices; Gastrointestinal bleeding; Hemostasis; Therapy
Core Tip	There is little evidence regarding the economic impact of standard endoscopic cyanoacrylate therapy vs endoscopic ultrasound (EUS)-guided endovascular therapy in the management of gastric varices. In this retrospective study, we found that patients treated with endoscopic cyanoacrylate injection required hospitalization and had a significantly higher total treatment cost in comparison to those treated with an EUS-guided therapy. The incremental cost-effectiveness ratio analysis shows that in endoscopic therapy, each early rebleeding, adverse events, and day of hospitalization increased health-related costs on United States $ 2670.80, United States $ 8012.40, United States $ 127.18 per presented event, respectively, when comparing with coils + cyanoacrylate group cost and presented events. Each inevitable death on the endoscopic group represented a health-related cost increase on United States $ 8012.40 in comparison with EUS-guided therapy.
Publish Date	2021-01-10 12:31
Citation	Robles-Medranda C, Nebel JA, Puga-Tejada M, Oleas R, Baquerizo-Burgos J, Ospina-Arboleda J, Valero M, Pitanga-Lukashok H. Cost-effectiveness of endoscopic ultrasound-guided coils plus cyanoacrylate injection compared to endoscopic cyanoacrylate injection in the management of gastric varices. World J Gastrointest Endosc 2021; 13(1): 13-23
URL	https://www.wjgnet.com/1948-5190/full/v13/i1/13.htm
DOI	https://dx.doi.org/10.4253/wjge.v13.i1.13

Full Article (PDF)	WJGE-13-13.pdf
Full Article (Word)	WJGE-13-13.docx
Manuscript File	59899_Auto_Edited.docx
Answering Reviewers	59899-Answering reviewers.pdf
Audio Core Tip	59899-Audio core tip.m4a
Biostatistics Review Certificate	59899-Biostatistics statement.pdf
Clinical Trial Registration Statement	59899-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	59899-Conflict-of-interest statement.pdf
Copyright License Agreement	59899-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	59899-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	59899-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	59899-Language certificate.pdf
Peer-review Report	59899-Peer-review(s).pdf
Scientific Misconduct Check	59899-Scientific misconduct check.pdf
Scientific Editor Work List	59899-Scientific editor work list.pdf