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2/5/2021 1:41:02 PM | Browse: 640 | Download: 1397
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Received |
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2020-10-20 02:20 |
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Peer-Review Started |
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2020-10-20 02:20 |
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First Decision by Editorial Office Director |
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2020-12-08 03:09 |
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Return for Revision |
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2020-12-08 03:09 |
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Revised |
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2020-12-21 08:48 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2020-12-29 12:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2020-12-29 19:01 |
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Articles in Press |
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2020-12-29 19:01 |
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Edit the Manuscript by Language Editor |
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2021-01-15 18:38 |
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Typeset the Manuscript |
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2021-02-02 14:39 |
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Publish the Manuscript Online |
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2021-02-05 10:20 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Demethylation of miR-34a up-regulates membrane palmitoylated proteins expression and promotes the apoptosis of liver cancer cell
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fu-Yong Li, Ting-Yong Fan, Hao Zhang and Yu-Min Sun |
| Funding Agency and Grant Number |
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| Corresponding Author |
Ting-Yong Fan, MD, Chief Physician, Department of Radiation Oncology, Shandong Cancer Hospital affiliated to Shandong University, No. 440 Jiyan Road, Jinan 250117, Shandong Province, China. fantcwq50216@163.com |
| Key Words |
Liver cancer; miR-34a; Membrane palmitoylated proteins; Methylation; Cell apoptosis; Caspase 3 |
| Core Tip |
This study confirmed the relationship of miR-34a hypermethylation with membrane palmitoylated proteins (MPP2) expression by investigating the changes of biological function and MPP2 expression level of liver cancer cells after miR-34a demethylation. miR-34a can inhibit the occurrence of liver cancer by up-regulating MPP2, and its demethylation in liver cancer cells is a potential method of liver cancer treatment. In essence, the miR-34a methylation is located on the upstream of its binding site with P53. Therefore, it is valuable to study the role of miR-34a methylation/demethylation on the expression level of upstream regulatory factors such as P53, and to explore its function in the future. |
| Publish Date |
2021-02-05 10:20 |
| Citation |
Li FY, Fan TY, Zhang H, Sun YM. Demethylation of miR-34a up-regulates membrane palmitoylated proteins expression and promotes the apoptosis of liver cancer cell. World J Gastroenterol 2021; 27(6): 470-486 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i6/470.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i6.470 |
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