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2/5/2021 1:41:02 PM | Browse: 53 | Download: 69
Publication Name World Journal of Gastroenterology
Manuscript ID 60177
Country/Territory China
2020-10-20 02:20
Peer-Review Started
2020-10-20 02:20
To Make the First Decision
Return for Revision
2020-12-08 03:09
2020-12-21 08:48
Second Decision
2020-12-29 12:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-12-29 19:01
Articles in Press
2020-12-29 19:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-01-15 18:38
Typeset the Manuscript
2021-02-02 14:39
Publish the Manuscript Online
2021-02-05 10:20
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Demethylation of miR-34a up-regulates membrane palmitoylated proteins expression and promotes the apoptosis of liver cancer cell
Manuscript Source Unsolicited Manuscript
All Author List Fu-Yong Li, Ting-Yong Fan, Hao Zhang and Yu-Min Sun
Funding Agency and Grant Number
Corresponding Author Ting-Yong Fan, MD, Chief Physician, Department of Radiation Oncology, Shandong Cancer Hospital affiliated to Shandong University, No. 440 Jiyan Road, Jinan 250117, Shandong Province, China. fantcwq50216@163.com
Key Words Liver cancer; miR-34a; Membrane palmitoylated proteins; Methylation; Cell apoptosis; Caspase 3
Core Tip This study confirmed the relationship of miR-34a hypermethylation with membrane palmitoylated proteins (MPP2) expression by investigating the changes of biological function and MPP2 expression level of liver cancer cells after miR-34a demethylation. miR-34a can inhibit the occurrence of liver cancer by up-regulating MPP2, and its demethylation in liver cancer cells is a potential method of liver cancer treatment. In essence, the miR-34a methylation is located on the upstream of its binding site with P53. Therefore, it is valuable to study the role of miR-34a methylation/demethylation on the expression level of upstream regulatory factors such as P53, and to explore its function in the future.
Publish Date 2021-02-05 10:20
Citation Li FY, Fan TY, Zhang H, Sun YM. Demethylation of miR-34a up-regulates membrane palmitoylated proteins expression and promotes the apoptosis of liver cancer cell. World J Gastroenterol 2021; 27(6): 470-486
Url https://www.wjgnet.com/1007-9327/full/v27/i6/470.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i6.470
Full Article (PDF) WJG-27-470.pdf
Full Article (Word) WJG-27-470.docx
Manuscript File 60177-Review-Filipodia.CLdocx.docx
Answering Reviewers 60177-Answering reviewers.pdf
Audio Core Tip 60177-Audio core tip.mp3
Biostatistics Review Certificate 60177-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 60177-Conflict-of-interest statement.pdf
Copyright License Agreement 60177-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 60177-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 60177-Language certificate.pdf
Supplementary Material 60177-Supplementary material.pdf
Peer-review Report 60177-Peer-review(s).pdf
Scientific Misconduct Check 60177-Bing-Gong ZM-1.png
Scientific Misconduct Check 60177-CrossCheck.png
Scientific Misconduct Check 60177-Scientific misconduct check.pdf
Scientific Editor Work List 60177-Scientific editor work list.pdf