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5/26/2021 7:17:47 AM | Browse: 340 | Download: 992
Publication Name World Journal of Biological Chemistry
Manuscript ID 60242
Country/Territory Brazil
Received
2020-10-25 17:28
Peer-Review Started
2020-10-25 17:29
To Make the First Decision
Return for Revision
2020-12-24 18:59
Revised
2021-01-06 19:41
Second Decision
2021-02-20 02:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-02-25 19:13
Articles in Press
2021-02-25 19:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-03-25 07:51
Typeset the Manuscript
2021-05-10 08:14
Publish the Manuscript Online
2021-05-26 07:12
ISSN 1949-8454 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Basic Study
Article Title Polyglutamylase activity of tubulin tyrosine ligase like 4 is negatively regulated by the never in mitosis gene A family kinase never in mitosis gene A -related kinase 5
Manuscript Source Unsolicited Manuscript
All Author List Talita Diniz Melo-Hanchuk and Jörg Kobarg
Funding Agency and Grant Number
Funding Agency Grant Number
Fundação de Amparo à Pesquisa do Estado São Paulo (FAPESP; São Paulo, Brazil) through Grant Temático 2017/03489-1
Corresponding Author Jörg Kobarg, PhD, Full Professor, Faculty of Pharmaceutical Sciences, University of Campinas, 200 Cândido Portinari, Campinas 13083-862, Brazil. jorgkoba@unicamp.br
Key Words Kinase; Poly glutamylation; Never in mitosis gene A-related kinase 5; Tubulin tyrosine ligase like 4; Micotubles; Post translational regulation
Core Tip Tubulins are modified extensively by post-translational processes such as polyglutamylation. Considering the diversity of microtubule polyglutamylation and the existence of many non-tubulin substrates, it is important to understand how the effector enzymes, the tubulin tyrosine ligase like (TTLL) proteins, are regulated. TTLL4 interacts with never in mitosis gene A (NIMA)-related kinase 5, a member of the mitotic NIMA-related kinases. We demonstrate NIMA-related kinase 5 as a potential regulator of polyglutamylation through TTLL4’s activity control. Here we provided the first relation of regulation of TTLL4 activity through phosphorylation, besides demonstrating the potential control of polyglutamylation through Nek family members in human cells.
Publish Date 2021-05-26 07:12
Citation Melo-Hanchuk TD, Kobarg J. Polyglutamylase activity of tubulin tyrosine ligase like 4 is negatively regulated by the never in mitosis gene A family kinase never in mitosis gene A -related kinase 5. World J Biol Chem 2021; 12(3): 38-51
URL https://www.wjgnet.com/1949-8454/full/v12/i3/38.htm
DOI https://dx.doi.org/10.4331/wjbc.v12.i3.38
Full Article (PDF) WJBC-12-38.pdf
Manuscript File 60242_Auto_Edited_LM-Webster J_TDMH jk[21609]-Clear.docx
Answering Reviewers 60242-Answering reviewers.pdf
Audio Core Tip 60242-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 60242-Conflict-of-interest statement.pdf
Copyright License Agreement 60242-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 60242-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 60242-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 60242-Language certificate.pdf
Supplementary Material 60242-Supplementary material.pdf
Peer-review Report 60242-Peer-review(s).pdf
Scientific Misconduct Check 60242-Bing-Chen XF-1.png
Scientific Misconduct Check 60242-Scientific misconduct check.pdf
Scientific Editor Work List 60242-Scientific editor work list.pdf