Publication Name	World Journal of Gastroenterology
Manuscript ID	60448
Country	China

Received	2020-11-04 12:57
Peer-Review Started	2020-11-04 12:58
First Decision by Editorial Office Director	2020-12-24 04:10
Return for Revision	2020-12-24 04:10
Revised	2020-12-29 11:32
Publication Fee Transferred
Second Decision by Editor	2021-01-06 12:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2021-01-06 18:58
Articles in Press	2021-01-06 18:58
Edit the Manuscript by Language Editor	2021-01-10 05:15
Typeset the Manuscript	2021-01-13 01:12
Publish the Manuscript Online	2021-01-14 11:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Serum vitamin D and vitamin-D-binding protein levels in children with chronic hepatitis B
Manuscript Source	Unsolicited Manuscript
All Author List	Cai-Zhi Huang, Jie Zhang, Lin Zhang, Cui-Hua Yu, Yi Mo and Li-Ya Mo
Funding Agency and Grant Number	Funding Agency Grant Number Hunan Provincial Health Commission Science Foundation of China 20200017
Corresponding Author	Li-Ya Mo, MBBS, Chief Technician, Director, Director, Professor, Department of Laboratory Medicine, Hunan Children’s Hospital, No. 86 Ziyuan Road, Changsha 410007, Hunan Province, China. 643183753@qq.com
Key Words	Chronic hepatitis B; Children; Vitamin D; Vitamin-D-binding protein; Hepatitis B virus
Core Tip	Serum vitamin D and vitamin-D-binding protein (VDBP) levels are associated with hepatitis B. The association of vitamin D and VDBP with hepatitis B virus (HBV) replication and hepatic fibrosis in children with chronic hepatitis B (CHB) has rarely been reported. We found that low level of serum 25-hydroxy vitamin D [25(OH)D] is an independent factor associated with development of hepatic fibrosis, and it could be valuable for maintaining sufficient 25(OH)D level to prevent or delay hepatic fibrosis in children with CHB. VDBP is negatively correlated with HBV replication, and VDBP analogs might be considered for management of CHB.
Publish Date	2021-01-14 11:34
Citation	Huang CZ, Zhang J, Zhang L, Yu CH, Mo Y, Mo LY. Serum vitamin D and vitamin-D-binding protein levels in children with chronic hepatitis B. World J Gastroenterol 2021; 27(3): 255-266
URL	https://www.wjgnet.com/1007-9327/full/v27/i3/255.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i3.255

Full Article (PDF)	WJG-27-255.pdf
Full Article (Word)	WJG-27-255.docx