Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	60773
Country	Brazil

Received	2020-11-25 20:13
Peer-Review Started	2020-11-25 20:13
First Decision by Editorial Office Director	2021-01-07 01:30
Return for Revision	2021-01-07 19:30
Revised	2021-01-20 14:45
Publication Fee Transferred
Second Decision by Editor	2021-04-25 12:26
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2021-04-25 13:13
Articles in Press	2021-04-25 13:13
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-04-29 03:12
Publish the Manuscript Online	2021-04-30 06:05

ISSN	2150-5349 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Overview of drug induced liver injury in Brazil: What is the role of public health policy on the evidence?
Manuscript Source	Invited Manuscript
All Author List	Matheus William Becker, Karin Hepp Schwambach, Michele Lunardelli and Carine Raquel Blatt
Funding Agency and Grant Number
Corresponding Author	Matheus William Becker, MSc, Pharmacist, Graduate Program in Medicine - Hepatology, Federal University of Health Sciences of Porto Alegre, Sarmento Leite, 245 Street, Porto Alegre 90050-001, RS, Brazil. matheuswbecker@gmail.com
Key Words	Chemical and drug-induced liver injury; Pharmacovigilance; Pharmacoepidemiology; Adverse effects; Infectious disease medicine; Hepatotoxicity
Core Tip	Hepatotoxicity is the main cause of safety-related drug marketing withdrawals and could be responsible for irreversible and fatal injuries. A systematic review of Brazilian studies was found 32 studies and the hepatotoxicity ranged from one to 57%, lead by isoniazid, rifampicin, and pyrazinamide. Few studies reported algorithm to assess causality and twenty-two different criteria for hepatotoxicity were found. Standardization of parameter of drug-induced liver injury and greater effort in pharmacovigilance could contribute to learn more about DILI's epidemiology in Brazil.
Publish Date	2021-04-30 06:05
Citation	Becker MW, Schwambach KH, Lunardelli M, Blatt CR. Overview of drug induced liver injury in Brazil: What is the role of public health policy on the evidence? World J Gastrointest Pharmacol Ther 2021; 12(3): 40-55
URL	https://www.wjgnet.com/2150-5349/full/v12/i3/40.htm
DOI	https://dx.doi.org/10.4292/wjgpt.v12.i3.40

Full Article (PDF)	WJGPT-12-40.pdf
Full Article (Word)	WJGPT-12-40.docx
Manuscript File	60773_Auto_Edited-ZMG.docx
Answering Reviewers	60773-Answering reviewers.pdf
Audio Core Tip	60773-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	60773-Conflict-of-interest statement.pdf
Copyright License Agreement	60773-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	60773-Language certificate.pdf
Peer-review Report	60773-Peer-review(s).pdf
Scientific Misconduct Check	60773-Scientific misconduct check.pdf
Scientific Editor Work List	60773-Scientific editor work list.pdf
CrossCheck Report	60773-CrossCheck report.pdf